微卫星与肺重复癌的研究进展  

Research Progress of Microsatellite and Multiple Primary Lung Cancer

作　　者：王鑫[1] 沈诚[1] 田龙[1] 车国卫[1] 

机构地区：[1]四川大学华西医院胸外科,成都610041

出　　处：《中国胸心血管外科临床杂志》2014年第5期670-674,共5页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金资助项目(81071929)~~

摘　　要：微卫星（microsatellite,MS）是指以少数几个核苷酸（多为2～4个）为单位多次串联重复的DNA序列。肺重复癌（肺多原发癌,multiple primary lung cancer）是指一侧肺或两侧肺的不同部位发生两个或两个以上原发癌,其组织类型相同或不同,但各肿瘤之间无从属关系,每个肿瘤的发生有着各自独立的成瘤因素。微卫星异常与肺重复癌的发生及发展密切相关。本文主要综述：1微卫星的概念及产生机制;2微卫星异常;3肺重复癌的概念及分类;4微卫星对肺重复癌的早期诊断和预后治疗的影响。A microsatellite is a short, repetitive sequence of DNA （usually 2 to 4 nucleotides in length）. Multiple primary lung cancers （MPLC） are more than one primary lung cancer lesions arising synchronously in different locations of the same or different side of the lung. These neoplasms may have same or different histological types, but one lesion is not a metastasis from another, as each neoplasm arises independently in the lung. Abnormal microsatellite changes are closely related to the pathogenesis and development of MPLC. In this review, several aspects are discussed： （1） definition and origin of microsateUite; （2） abnormal changes of microsateUite; （3） definition and categories of MPLC; （4） the influence of micros- atellite on early diagnosis, treatment and prognosis of MPLC.

关 键 词：微卫星不稳定性 杂合性缺失 肺重复癌 游离DNA 

分 类 号：R734.2[医药卫生—肿瘤]