Neuroprotective effects of vagus nerve stimulation on traumatic brain injury  

作　　者：Long Zhou Jinhuang Lin Junming Lin Guoju Kui Jianhua Zhang Yigang Yu 

机构地区：[1]Affiliated Dongnan Hospital of Xiamen University [2]the 175 Hospital of Chinese PLA,Trauma Neurosurgery Center of Nanjing Military Region [3]The 73131 Corps of Chinese PLA

出　　处：《Neural Regeneration Research》2014年第17期1585-1591,共7页中国神经再生研究（英文版）

摘　　要：Previous studies have shown that vagus nerve stimulation can improve the prognosis of trau- matic brain injury. The aim of this study was to elucidate the mechanism of the neuroprotective effects of vagus nerve stimulation in rabbits with brain explosive injury. Rabbits with brain ex- plosive injury received continuous stimulation （10 V, 5 Hz, 5 ms, 20 minutes） of the right cervical vagus nerve. Tumor necrosis factor-a, interleukin-l~ and interleukin-10 concentrations were detected in serum and brain tissues, and water content in brain tissues was measured. Results showed that vagus nerve stimulation could reduce the degree of brain edema, decrease tumor necrosis factor-a and interleukin-1β concentrations, and increase interleukin-10 concentration after brain explosive injury in rabbits. These data suggest that vagus nerve stimulation may exert neuroprotective effects against explosive injury via regulating the expression of tumor necrosis factor-a, interleukin-1 β and interleukin-10 in the serum and brain tissue.Previous studies have shown that vagus nerve stimulation can improve the prognosis of trau- matic brain injury. The aim of this study was to elucidate the mechanism of the neuroprotective effects of vagus nerve stimulation in rabbits with brain explosive injury. Rabbits with brain ex- plosive injury received continuous stimulation （10 V, 5 Hz, 5 ms, 20 minutes） of the right cervical vagus nerve. Tumor necrosis factor-a, interleukin-l~ and interleukin-10 concentrations were detected in serum and brain tissues, and water content in brain tissues was measured. Results showed that vagus nerve stimulation could reduce the degree of brain edema, decrease tumor necrosis factor-a and interleukin-1β concentrations, and increase interleukin-10 concentration after brain explosive injury in rabbits. These data suggest that vagus nerve stimulation may exert neuroprotective effects against explosive injury via regulating the expression of tumor necrosis factor-a, interleukin-1 β and interleukin-10 in the serum and brain tissue.

关 键 词：nerve regeneration brain injury vagus nerve stimulation tumor necrosis factor-a interleukin- lβ INTERLEUKIN-10 brain tissue pathology protection explosive injury mechanisms HYDROCEPHALUS neural regeneration 

分 类 号：R651.1[医药卫生—外科学]