INTERLEUKIN-10

作品数：162被引量：1113H指数：17
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Mesalazine alleviated the symptoms of spontaneous colitis in interleukin-10 knockout mice by regulating the STAT3/NF-κB signaling pathway
《World Journal of Gastroenterology》2025年第7期88-97,共10页Qian Chen Ya-Li Zhang Yong-Quan Shi Lie Zheng 
Supported by Xi’an Science and Technology Plan Project,No.23YXYJ0162;Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Plan Project,No.TZKN-CXRC-16;Project of Shaanxi Administration of Traditional Chinese Medicine,No.SZYKJCYC-2025-JC-010;Shaanxi Province Key Research and Development Plan Project-Social Development Field,No.S2025-YF-YBSF-0391;the Science and Technology Innovation Cultivation Program of Longhua Hospital affiliated to Shanghai University of Chinese Medicine,No.YD202220。
BACKGROUND Excessive endoplasmic reticulum(ER)stress in intestinal epithelial cells can lead to damage to the intestinal mucosal barrier,activate the signal transducer and activator of transcription 3(STAT3)/nuclear f...
关键词：MESALAZINE Ulcerative colitis Interleukin-10-/-mice Signal transducer and activator of transcription 3/nuclear factor kappa B signaling pathway Endoplasmic reticulum stress Inflammatory bowel disease 
Cross-sectional analysis of blood leukocyte responsiveness to interleukin-10 and interleukin-6 across age and physical activity level
《Translational Exercise Biomedicine》2024年第3期255-263,共9页Hashim Islam Jordan Boultbee Garett S.Jackson Alice L.Mui Jonathan P.Little 
H.I.was supported by a Natural Sciences and Engineering Council(NSERC)postdoctoral fellowship and a Michael Smith Health Research BC Research Trainee Award;J.B.was supported by and NSERC Undergraduate Student Research Award;G.S.J.was supported by an Indigenous Scholar’s Award;J.P.L is supported by an NSERC Discovery Grant(RGPIN-2019-05204);Killam Accelerator Research Fellowship(AWD-018101).
Objectives To determine how the anti-inflammatory actions of interleukin-10(IL-10)and IL-6 differ across age and physical activity levels.Methods Using a cross-sectional design,fasted blood samples were obtained from ...
关键词：chronic inflammation MONOCYTES lymphocytes STAT3 INFLAMMAGING exercise 
Interleukin-10 gives exhausted chimeric antigen receptor(CAR)T cells a second breath
《Cancer Communications》2024年第7期787-790,共4页Christoph Heuser-Loy 
European Innovation Council and Small and Medium-sized Enterprises Executive Agency,Grant/Award Number:101070740。
Adoptive cell therapy(ACT)represents a major pillar of modern immuno-oncology.Naturally or synthetically endowed with the ability to recognize tumor-associated antigens,tumor-infiltrating lymphocytes(TILs)or T cells e...
关键词：INTERLEUKIN STIMULATION FIGURE 
Evaluation of angiotensin converting enzyme insertion/deletion, alpha adducin (ADD1) G460W, and IL-10 gene polymorphisms, and determination of prognostic effects in idiopathic sudden sensorineural hearing loss
《Journal of Otology》2024年第2期97-105,共9页Vural Akın Mehmet Emre Sivrice Kuyas Hekimler Oztürk Hasan Yasan Mustafa Tüz Erdogan Okur Yusuf Çagdas Kumbul 
supported by The Coordinatorship of Scientific Research Projects Department,Süleyman Demirel University(Grant Number:TTU-2021-8402).
Objective:The aim of this study was to examine angiotensin converting enzyme(ACE)insertion/deletion,alpha adducin,and interleukin-10(IL-10)gene polymorphisms(GPs)in terms of both idiopathic sudden sensorineural hearin...
关键词：Alpha adducin Idiopathic sudden sensorineural hearing loss Angiotensin converting enzyme Gene polymorphism INTERLEUKIN-10 
Interleukin-10 suppresses lipid metabolism-mediated intestinal inflammation
《Life Metabolism》2024年第3期3-5,共3页Tristram A.J.Ryan Ivan Zanoni 
Ivan Zanoni is supported by NIH grants(2R01AI121066,2R01DK115217,1R01AI165505,1R01AI170632);the Lloyd J.Old STAR Program(CRI3888);holds an Investigators in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund.
In a recent paper published in Nature,York et al.reported that the anti-inflammatory cytokine interleukin(IL)-10 regulates sphingolipid metabolism to limit NF-κB-mediated inflammation.Deletion of Il10 in mice,or gene...
关键词：METABOLISM INFLAMMATION 
Effects of interleukin-10 treated macrophages on bone marrow mesenchymal stem cells via signal transducer and activator of transcription 3 pathway
《World Journal of Stem Cells》2024年第5期560-574,共15页Meng-Hao Lyu Ce Bian Yi-Ping Dou Kang Gao Jun-Ji Xu Pan Ma 
BACKGROUND Alveolar bone defects caused by inflammation are an urgent issue in oral implant surgery that must be solved.Regulating the various phenotypes of macrophages to enhance the inflammatory environment can sign...
关键词：MACROPHAGES INTERLEUKIN-10 Bone marrow mesenchymal stem cells Signal transducer and activator of transcription 3 Inflammatory response 
CD3ε of a pan T cell marker involved in mouse Aspergillus fumigatus keratitis
《International Journal of Ophthalmology(English edition)》2024年第4期616-624,共9页Wen-Hao Shi Li-Mei Wang Hai-Jing Yan Shi-Long Liu Xian Yang Xue-JiaoYang Cheng-Ye Che 
Supported by the National Natural Science Foundation of China(No.82171019);the Natural Science Foundation of Shandong Province(No.ZR2021MH368);Traditional Chinese Medicine Research Project of Qingdao(No.2020-zyy055);Shandong Qingdao Outstanding Health Professional Development Fund.
AIM:To explore whether CD3ε is involved in the adaptive immunity of Aspergillus fumigatus(A.fumigatus)keratitis in mice and the role of innate and adaptive immunity in it.METHODS:Mice models of A.fumigatus keratitis ...
关键词：CD3ε adaptive immunity Aspergillus fumigatus keratitis INTERLEUKIN-10 
Low interleukin-10 level indicates a good prognosis in Salmonella enterica serovar typhimurium-induced pediatric hemophagocytic lymphohistiocytosis:A case report
《World Journal of Clinical Cases》2024年第9期1660-1668,共9页Yuan-Yuan Chen Xiang-Zhi Xu Xiao-Jun Xu 
Supported by Zhejiang Province Health and Wellness Science and Technology Program in 2022,China,No.2022RC202.
BACKGROUND Secondary hemophagocytic lymphohistiocytosis(sHLH)triggered by Salmonella enterica serovar Typhimurium is rare in pediatric patients.There is no consensus on how to treat S.typhimurium-triggered sHLH.CASE S...
关键词：Hemophagocytic lymphohistiocytosis Cytokine pattern Interferon gamma INTERLEUKIN-10 Salmonella enterica serovar Typhimurium Case report 
Oxidative stress-initiated one-carbon metabolism drives the generation of interleukin-10-producing B cells to resolve pneumonia被引量：1
《Cellular & Molecular Immunology》2024年第1期19-32,共14页Ying Fu Baichao Yu Qi Wang Zhou Lu Hushan Zhang Dan Zhang Feifei Luo Ronghua Liu Luman Wang Yiwei Chu 
supported by the General Program of the National Natural Science Foundation of China(81971493,81771736);the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(82121002);Major Program of National Natural Science Foundation of China(821300501,82330053);Shanghai Rising-Star Program(20QA1407900);Innovative Research Team of High-level Local Universities in Shanghai.
The metabolic reprogramming underlying the generation of regulatory B cells during infectious diseases remains unknown.Using a Pseudomonas aeruginosa-induced pneumonia model,we reported that IL-10-producing B cells(IL...
关键词：IL-10-producing B cell Reactive oxygen species One-carbon metabolism H3K4me PNEUMONIA 
Interleukin-10 multitasking in allergic airway inflammation被引量：1
《Cellular & Molecular Immunology》2023年第12期1530-1532,共3页Rudi W.Hendriks 
Allergic asthma reflects an imbalance of pro-and anti-inflammatory components of the immune system,and in asthma patients,endogenous mechanisms that maintain homeostasis in the lung are thought to be defective.IL-10 i...
关键词：AIRWAY INFLAMMATION ALLERGIC 
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