Interleukin-10 suppresses lipid metabolism-mediated intestinal inflammation  

作　　者：Tristram A.J.Ryan Ivan Zanoni 

机构地区：[1]Division of Immunology and Division of Gastroenterology,Boston Children’s Hospital and Harvard Medical School,Boston,MA 02115,United States

出　　处：《Life Metabolism》2024年第3期3-5,共3页生命代谢（英文）

基　　金：Ivan Zanoni is supported by NIH grants(2R01AI121066,2R01DK115217,1R01AI165505,1R01AI170632);the Lloyd J.Old STAR Program(CRI3888);holds an Investigators in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund.

摘　　要：In a recent paper published in Nature,York et al.reported that the anti-inflammatory cytokine interleukin(IL)-10 regulates sphingolipid metabolism to limit NF-κB-mediated inflammation.Deletion of Il10 in mice,or genetic mutation of IL10 in humans,predisposes to inflammatory bowel disease,which may be overcome by restoring homeostatic sphingolipid metabolism.

关 键 词：METABOLISM INFLAMMATION 

分 类 号：R574[医药卫生—消化系统]