新型吗啉类化合物的合成及抗实验性抑郁活性研究  

Synthesis of New Morpholine Compounds and Their Antidepressive Activities

作　　者：梁俊[1] 肖新荣[1] 何军[1] 

机构地区：[1]南华大学化学化工学院,湖南衡阳421001

出　　处：《南华大学学报（自然科学版）》2014年第3期87-91,共5页Journal of University of South China：Science and Technology

基　　金：湖南省衡阳市社会发展科技支撑计划基金资助项目(2011ks14)

摘　　要：设计合成了7个未见报道的新型吗啉类化合物,通过IR、NMR、ESI-MS和元素分析对目标化合物结构进行了表征.利用小鼠强迫游泳及悬尾两个抗抑郁药理模型对所合成的化合物进行抗抑郁药理活性筛选,进行了初步的药效评价研究.结果表明这些化合物显示了不同程度的抗抑郁活性,同等剂量下部分化合物的体内抗抑郁作用显著强于空白组,其中芳香环的3位上具有氟取代基的化合物,抗抑郁活性最高,有进一步研究的价值.Seven novel morpholine compounds had been designed and synthetized,the structure of target compounds were confirmed by IR,NMR,ESI-MS and elemental analysis. All synthetized compounds were tested by forced swimming test and tail suspension test in mice. The result showed that these compounds display anti-depression activity of different degrees and the anti-depression effect of part of compounds with the same dose was significantly better than that of the blank group. The compounds containing a fluorinated substituent at the 3-position of aromatic ring exhibited a higher activity than others. Some of them are worth to be studied further.

关 键 词：吗啉类化合物 合成 抗抑郁药理模型 抗抑郁活性 

分 类 号：R914.5[医药卫生—药物化学]