复方桑黄口服液粗多糖对小鼠免疫功能的影响  

Effect of Compound Phellinus igniarius Oral Liquid's Polysaccharide on Mouse's Immunity Function

作　　者：林希[1] 傅海庆[1] 李鸣[2] 蔡玮[1] 傅华英[3] 陈团伟[4] 

机构地区：[1]福建农林大学金山学院,福州350002 [2]福建省药品检验所,福州350001 [3]福建农林大学作物科学学院,福州350002 [4]福建农林大学食品科学学院,福州350002

出　　处：《中国农学通报》2014年第27期304-308,共5页Chinese Agricultural Science Bulletin

基　　金：国家级大学生创新训练计划项目"以药用菌桑黄多糖为主要成分的增强免疫功能食品的研制"(201314046008);福建省教育厅A;B类项目"药用菌桑黄多糖的提取及其增强免疫功能食品的研制"(JA12378;JB12286)

摘　　要：研究复方桑黄口服液粗多糖对小鼠免疫功能的影响。从小鼠碳廓清实验、小鼠腹腔巨噬细胞吞噬鸡红细胞实验(半体内法)、脏器与体重比值、小鼠自然杀伤(natural killer,NK)细胞活性测定(乳酸脱氢酶测定法)等四个方面进行研究。结果表明:复方桑黄口服液的高剂量组(40 mL/kg)能明显增强小鼠碳廓清能力,中(20 mL/kg)、高剂量组能明显增强小鼠巨噬细胞吞噬鸡红细胞的吞噬百分率和吞噬指数,低(10 mL/kg)、中、高剂量组能明显增强小鼠NK细胞活力功能。这表明复方桑黄口服液具有增强单核-巨噬细胞功能、增强NK细胞活力功能,结论:复方桑黄口服液具有增强免疫功能的作用,可显著提高机体特异性和非特异性免疫功能。Phellinus igniarius is a kind of rare officinal fungi. The paper aims to study the effect of compound P. igniarius oral liquid＇ s polysaccharide on mouse＇ s immunity function. From mouse carbon clearance test, macrophage phagocytosis of chicken red blood cells （semi in vivo method）, organ and body weight ratio, natural killer （NK） cell activity in mouse （determination of The results showed that high dose （40 mL/kg） of the lactate dehydrogenase assay） were studied in four aspects. compound P. igniarius oral liquid could obviously enhance the ability of carbon clearance in mouse; middle （20 enhance the phagocytosis phagocytic index; low （10 of chicken red blood cell mL/kg） and high dose treatments could significantly s of mouse macrophage phagocytic percentage and mL/kg）, middle and high dose treatments could significantly enhance the NK cell activity in mouse. These shows that compound P. igniarius oral liquid has enhanced mononuclear macrophage function, the activity of NK cell function. In conclusion, compound P. igniarius oral liquid＇ s polysaccharide could enhance immune function, can significantly improve the specificity and non-specificity immune function.

关 键 词：桑黄 复方桑黄口服液 粗多糖 小鼠 免疫功能 

分 类 号：R967[医药卫生—药理学]