The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population  

作　　者：LIU LiNa WANG ChengYe LU Xiang XIAO FuHui WANG HuaWei YANG LiQin XU LiangYou KONG QingPeng 

机构地区：[1]State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences [2]Key Laboratory of Cultivating and Utilization of Resource Insects of State Forestry Administration, Research Institute of Resource Insects,Chinese Academy of Forestry [3]Dujiangyan Longevity Research Center

出　　处：《Science China(Life Sciences)》2014年第10期1024-1027,共4页中国科学（生命科学英文版）

基　　金：supported by the National Basic Research Program of China(2013CB530802);Yunnan Province(2011FA024);the National Natural Science Foundation of China(31100909);the Chinese Academy of Sciences

摘　　要：MNS16A, a variable number of tandem repeats polymorphism in the TERT gene, has been suggested to regulate telomerase activity. As telomerase activity has been reported to be related to life-span, we hypothesized that this polymorphism might affect human longevity by controlling the length of the telomere. To test this hypothesis, we collected 446 unrelated pericentenarian individuals （age）90, mean 94.45±3.45 years） and 332 normal controls （age 22-53, mean 35.0±12.0 years） from Dujiangyan, Sichuan, China. We typed the MNS16A polymorphism in both groups, and compared the allele and genotype frequencies between the peri-centenarian and control groups using the chi-squared test. There was no significant difference between the peri-centenarian and control groups. Thus, the MNS16A polymorphism in TERT might not influence human life-span, at least in the Hart Chinese population studied here.MNS16A,a variable number of tandem repeats polymorphism in the TERT gene,has been suggested to regulate telomerase activity.As telomerase activity has been reported to be related to life-span,we hypothesized that this polymorphism might affect human longevity by controlling the length of the telomere.To test this hypothesis,we collected 446 unrelated pericentenarian individuals(age≥90,mean 94.45±3.45 years)and 332 normal controls(age 22-53,mean 35.0±12.0 years)from Dujiangyan,Sichuan,China.We typed the MNS16A polymorphism in both groups,and compared the allele and genotype frequencies between the peri-centenarian and control groups using the chi-squared test.There was no significant difference between the peri-centenarian and control groups.Thus,the MNS16A polymorphism in TERT might not influence human life-span,at least in the Han Chinese population studied here.

关 键 词：TELOMERASE LONGEVITY MNS16A polymorphism peri-centenarian 

分 类 号：R394[医药卫生—医学遗传学]