非强效卵巢刺激的地中海贫血患者胚胎种植前遗传学诊断助孕治疗结局  

Assisted Reproductive Outcomes of Thalassemia Carriers Undergoing Preimplantation Genetic Diagnosis with Routine Ovarian Stimulation

作　　者：袁媛[1] 袁茜[1] 徐艳文[1] 周灿权[1] 

机构地区：[1]中山大学附属第一医院生殖医学中心∥广东省生殖医学重点实验室,广东广州510080

出　　处：《中山大学学报（医学科学版）》2014年第5期753-757,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广州市科技计划项目(201300000097)

摘　　要：【目的】观察非强效卵巢刺激的地中海盆血(地贫)患者胚胎种植前遗传学诊断助孕治疗结局,探讨特殊助孕目的下地贫患者卵巢反应性及合适的刺激强度。【方法】收集70名因地中海贫血行胚胎种植前遗传学诊断治疗(实验组)及57名因男方因素行单精子卵胞浆内注射患者(对照组),比较其在同等强度刺激下的卵巢反应及临床结局。【结果】在基础内分泌水平及卵巢刺激强度可比情况下,实验组可移植胚胎数显著少于对照组,差异具有统计学意义(P=0.021);两组患者的获卵数、临床妊娠率、每移植周期活产率均没有统计学差异。【结论】地贫状态不影响患者卵巢反应性,在非强效卵巢刺激下,行胚胎种植前遗传学诊断助孕治疗的地贫患者也可获得满意的临床结局。[Objective] To investigate the assisted reproductive outcomes of thalassemia carriers undergoing preimplantation genetic diagnosis with routine ovarian stimulation,and to explore the ovarian response characteristics of thalassemia carriers and the proper ovarian stimulation intensity if they sought after PGD treatment.[Method] We reviewed the outcome of couples that both carried mutation attributed to thalassemia （study group） and couples in which with male factors underwent ICSI （control group）.All patients received routine ovarian stimulation.Ovarian response,oocyte number and pregnancy outcome were recorded.[Results] No difference was observed for patient demographic and baseline clinical characteristics.No difference in COS parameters was observed for the total dose of recombinant FSH and the number of retrieved oocytes.However,the number of embryos transferable was significant lower in study group than in the control （P =0.021）.For both groups,pregnancy outcomes including clinical pregnancy rate and live birth rate were similar per cycle.[Conclusion] Ovarian response is not impaired by thalassemia carrier status and satisfactory clinical outcomes could be achieved with routine ovarian stimulation for thalassemia carriers undergoing preimplantation genetic diagnosis.

关 键 词：地中海贫血 胚胎种植前遗传学诊断 卵巢刺激 临床结局 

分 类 号：R715.5[医药卫生—妇产科学]