ERα辅调节因子在乳腺癌中的双重调控作用  

The Dual Function of ERα Coregulators in the Breast Cancer

作　　者：许兆伟 赵锋[1] 伍会健[1] 

机构地区：[1]大连理工大学生命科学与技术学院,大连116024

出　　处：《中国细胞生物学学报》2014年第10期1437-1442,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31171353);国家重点基础研究发展计划(973计划)(批准号:2011CB504201)资助的课题~~

摘　　要：在发达国家,乳腺癌一直是威胁女性健康的恶性肿瘤之一。雌激素受体α(estrogen receptor alpha,ERα)是一种配体依赖性的转录因子,其介导的基因转录调控在乳腺癌的增殖、分化、侵袭和转移等过程中发挥重要作用。ERα主要依赖于辅调节因子共同调控下游靶基因的表达。近年来,有研究证实,一些关键转录辅调节因子在调节ER转录活性的同时,也可以作为泛素E3连接酶,促进ERα的降解。该文详细介绍几种辅调节因子对ERα的双重调节作用,有助于从分子水平阐明不同类型乳腺癌中造成ERα表达量差异的机制,为乳腺癌的靶向治疗和预防提供理论依据。The health of women is facing the threat of malignant breast carcinoma, especially in many developed countries. Estrogen receptor alpha（ERα） is a kind of ligand dependent transcription factor, which mediates downstream targeted genes transcriptional regulation, playing an important role in the process including proliferation, differentiation and invasion of breast carcinoma cells. ERα regulates the expression of downstream target genes mainly depending on its coregulators. Recently, studies have confirmed that many coactivators or corepressors of ERα can significantly regulate it＇s transcriptional activation. Meanwhile, they act as ubiquitin E3 ligase to promote the degradation of ERα. Here, we review the dual function of ERα coregulators in breast cancer. This study may explain the molecular mechanism about ERα expression difference involved in different types of breast cancer cells and provide a new perspective on prevention and targeted therapy.

关 键 词：ERΑ 辅调节因子 乳腺癌 转录调控 泛素E3连接酶 

分 类 号：R737.9[医药卫生—肿瘤]