X射线交错互补修复基因3基因单体型与喉癌的关联分析  

Haplotype analysis of XRCC3 gene and laryngeal

作　　者：周旭[1] 戚颖[1] 

机构地区：[1]复旦大学附属中山医院耳鼻咽喉科,上海200032

出　　处：《临床耳鼻咽喉头颈外科杂志》2014年第21期1655-1657,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨X射线交错互补修复基因3(XRCC3)基因单体型和喉癌易感性的关联。方法:选择XRCC3基因4个标签SNP(rs12432907、rs861536、rs861537、rs861531),对310例喉癌患者(实验组)及310例健康人(对照组)进行基因分型。采用SHEsis软件构建单体型,比较基因型及单体型频率在2组之间的差异。结果:实验组、对照组rs12432907基因型频率比较,差异有统计学意义(P<0.05)。单体型分析结果显示,CCAG单体型分布频率实验组明显高于对照组,TCAG和TTAG分布频率实验组明显低于对照组,差异有统计学意义(均P<0.05)。结论:XRCC3基因单体型和喉癌的易感性具有明显关联。Objective：To explore the association of XRCC3 gene polymorphisms and haplotypes with laryngeal.Method：We selected 4tag SNPs（rs12432907,rs861536,rs861537,rs861531,rs861531）for the present study.310 laryngeal patients and 310 healthy control subject were genotyping.The distribution of genotypes and haplotypes in these two group was compared.Result：The distributions of rs12432907 was significantly different between these two groups.The CCAG haplotype frequency was higher in laryngeal group than that in control group.But TCAG and TTAG haplotype frequency was were lower in the laryngeal patient than that those in the control subject.Conclusion：XRCC3gene polymorphism was associated with the risk of laryngeal patients.

关 键 词：X射线交错互补修复基因3 喉肿瘤 单体型 单核苷酸多态性 

分 类 号：R739.6[医药卫生—肿瘤]