FAK、NF-κB及VEGF在非小细胞肺癌中的表达及临床意义  

Expression and Significance of FAK,NF-κB and VEGF in Non-small Cell Lung Cancer

作　　者：张柯晴 吕坤聚[2] 朱君祥[2] 

机构地区：[1]青岛大学医学院,山东266000 [2]中国人民解放军第401医院呼吸内科

出　　处：《中国组织化学与细胞化学杂志》2014年第6期529-533,共5页Chinese Journal of Histochemistry and Cytochemistry

摘　　要：目的探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)中FAK、NF-κBp65及VEGF-C的表达与NSCLC临床特征的关系。方法运用免疫组织化学Elivision法检测FAK、NF-κBp65及VEGF-C在75例NSCLC中的表达情况,以30例对应的癌旁正常组织作为对照。结果在NSCLC中FAK、NF-κBp65、VEGF-C的阳性表达率分别为57.3%(43/75)、85.3%(64/75)、65.3%(49/75),而在癌旁组织中三者的阳性率分别是13.3%(4/30)、16.7(5/30)、0%(0/30),三者的表达与肿瘤的分化程度、临床分期、淋巴结转移等密切相关,差异有统计学意义(P<0.05)。结论FAK、NF-κBp65、VEGF-C在NSCLC的发生和发展中起重要作用,以FAK、NF-κBp65和VEGF-C为中心的靶向治疗,可能成为NSCLC的治疗途径之一。Objective To investigate the expression of FAK(focal adhesion kinase),NF-kappaBP65(nuclear factor-kappaBP65)and VEGF-C(vascular endothelial growth factor-C)in non-small cell lung cancer(NSCLC)in order to detect their relationship with clinical pathologic features.Methods The immunohistochemical staining method was used to detect the expression of FAK,NF-κBP65and VEGF-C in NSCLC(n=75)and 30 normal paracancer tissues.Results The positive rates of FAK,NF-κBp65and VEGFC expressions were 57.3%(43/75),85.3%(64/75)and 65.3%(49/75)in NSCLC tissues but those in normal tissues were 13.3%(4/30),16.7(5/30)and 0%(0/30).The expression level of FAK,NF-κBp65and VEGF-C was closely related to cell differentiation,clinical stages and lymph node involvement(P<0.05).Conclusion Higher expression levels of FAK,NF-κBp65and VEGF-C play a crucial role in the carcinogenesis and progress of NSCLC.The treatment targeting FAK,NF-κBp65and VEGF-C may be a novel approach to NSCLC.

关 键 词：FAK NF-KB VEGF 免疫组织化学 肺肿瘤 

分 类 号：R734.2[医药卫生—肿瘤]