4例神经性肌强直患者电生理学和临床特点探讨  

Electrophysiology and Clinical Features of Neuromyotonia

作　　者：陈博[1] 王琼[1] 柯高潭 卜碧涛[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院神经内科,武汉430030

出　　处：《神经损伤与功能重建》2014年第6期482-484,共3页Neural Injury and Functional Reconstruction

摘　　要：目的:探讨神经性肌强直(NMT)的临床表现、肌电图及治疗特点。方法:回顾性分析临床确诊的4例NMT患者的临床表现、肌电图及治疗特点。结果:4例患者临床表现均以静息状态下肌肉颤搐为主,肌电图显示自发的、连续的、不规则的多重单个运动单元高频率放电,其中3例单纯卡马西平或苯妥英钠效果不佳,加用激素治疗后获痊愈。结论:卡马西平或苯妥英钠治疗获得性NMT可缓解症状,效果不佳时结合激素治疗,疗效显著,支持获得性NMT与免疫功能紊乱相关。Objective： To investigate the characteristics of neuromyotonia in clinical manifestation, electromyo-graphic features and treatment. Methods：The clinical manifestation, electromyographic features and treatment of four neuromyotonia cases were analyzed. Results：The four patients manifested muscle twitching at rest and EMG revealed spontaneous, continuous, irregularly occurring multiple motor unit discharges, firing at high frequency. Three out of the four patients were not cured by anti-epilepsy drugs such as Carbamazepine or Phenytoin before prednisone was added. Conclusion：The symptoms of acquired neuromyotonia can be alleviated by Carbamazepine or Phenytoin. The remarkable effect may be achieved by prednisone. The data supports the evidence that the ac-quired neuromyotonia is a disorders of mediated by autoimmunity.

关 键 词：神经性肌强直 肌纤维颤搐 电压门控钾通道 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.04[医药卫生—临床医学]