硫酸镁预防婴儿痉挛症ACTH治疗相关性高血压病例对照研究  

A case-control study about the preventive effect of magnesium sulfate on hypertention caused by ACTH in the treatment of infantile spasms

作　　者：刘秀国[1,2] 李久伟[3] 石秀玉[1] 鞠俊[1] 邹丽萍[1] 

机构地区：[1]中国人民解放军总医院儿童医学中心,北京100853 [2]河北省邢台市人民医院儿科,河北邢台054001 [3]首都医科大学附属北京儿童医院神经科,北京100045

出　　处：《临床儿科杂志》2014年第11期1013-1015,共3页Journal of Clinical Pediatrics

摘　　要：目的观察硫酸镁对促肾上腺皮质激素(ACTH)治疗婴儿痉挛症(IS)过程中高血压的预防作用。方法选取2011年5月至2013年10月住院的46例IS患儿,以入住医院分为硫酸镁组23例,给予硫酸镁联合ACTH治疗;对照组23例,单用ACTH治疗,疗程均为2周。观察比较两组高血压的发生率。结果硫酸镁组患儿没有出现高血压,全部完成疗程;对照组出现6例高血压,18例完成疗程。硫酸镁组在高血压的发生及疗程完成方面均优于对照组,差异有统计学意义(P<0.05)。结论硫酸镁能预防ACTH在治疗IS过程中高血压的发生,有利于完成疗程,尽早控制病情。Objective To examine the preventive effect of magnesium sulfate on hypertension caused by ACTH in the treatment of infantile spasms （IS）. Methods 46 children diagnosed as IS were recruited from two hospitals during May, 2011 to October, 2013.23 patients in group A （treatment group） were treated with magnesium sulfate and ACTH in hospital A;another 23 cases in group B （control group） were treated with ACTH only in hospital B. The therapy course was 2 weeks. Results Hyperten-sion was not observed in the treatment group, while 6 children were observed with hypertension in the control group. There was signiifcant difference between the two groups （P〈0.05）. Conclusions Magnesium sulfate could prevent the incidence of hyper-tension in the treatment of IS with ACTH, and beneift the completion of treatment course.

关 键 词：婴儿痉挛症 硫酸镁 促肾上腺皮质激素 高血压 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R725.4[医药卫生—临床医学]