难治性癫相关病理学最新研究进展  

Research progress on pathology of intractable epilepsy

作　　者：朴月善[1] 卢德宏[1] 

机构地区：[1]首都医科大学宣武医院病理科,北京100053

出　　处：《中国现代神经疾病杂志》2014年第12期1035-1040,共6页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：北京市卫生系统高层次卫生技术人才培养计划项目(项目编号:2011-3-095)~~

摘　　要：外科手术切除致灶的大力开展,为难治性癫的神经病理学研究提供了充足的病例资源。近年来,国际上关于皮质发育畸形和海马硬化的分类均有了新的研究成果和共识,同时结合分子生物学和分子遗传学的探索为我们认识癫相关病变的疾病谱系和发病机制提供了新的依据。未来几年,关于致灶的分子病理学及其致性的研究将成为热点。With increased surgical operation samples of intractable epilepsy, there are sufficient cases for neuropathological study. Some new studies and consensus on classification of malformations of cortical development or hippocampal sclerosis were proposed recently. Moreover, researches using molecular and genetic methods have provided new opinions for disease spectrum and pathogenesis of epilepsy associated lesions. In the next few years, further studies on the molecular pathology and epileptogenesis of the epileptic foci are necessary.

关 键 词：癫痫 颞叶 皮质发育畸形 海马 病理学 综述 

分 类 号：R742.1[医药卫生—神经病学与精神病学]