Epstein-Barr virus and Burkitt lymphoma  

作　　者：Martin Rowe Leah Fitzsimmons Andrew I Bell 

机构地区：[1]School of Cancer Sciences, University of Birmingham CMDS

出　　处：《Chinese Journal of Cancer》2014年第12期609-619,共11页

基　　金：supported by a grant from the Cancer Research UK,London(Programme Award C5575/A15032)

摘　　要：In 1964,a new herpesvirus,Epstein-Barr virus(EBV),was discovered in cultured tumor cells derived from a Burkitt lymphoma(BL)biopsy taken from an African patient.This was a momentous event that reinvigorated research into viruses as a possible cause of human cancers.Subsequent studies demonstrated that EBV was a potent growth-transforming agent for primary B cells,and that all cases of BL carried characteristic chromosomal translocations resulting in constitutive activation of the c-MYC oncogene.These results hinted at simple oncogenic mechanisms that would make Burkitt lymphoma paradigmatic for cancers with viral etiology.In reality,the pathogenesis of this tumor is rather complicated with regard to both the contribution of the virus and the involvement of cellular oncogenes.Here,we review the current understanding of the roles of EBV and c-MYC in the pathogenesis of BL and the implications for new therapeutic strategies to treat this lymphoma.In 1964, a new herpesvirus, Epstein-Barr virus （EBV）, was discovered in cultured tumor cells derived from a Burkitt lymphoma （BL） biopsy taken from an African patient. This was a momentous event that reinvigorated research into viruses as a possible cause of human cancers. Subsequent studies demonstrated that EBV was a potent growth-transforming agent for primary B cells, and that all cases of BL carried characteristic chromosomal translocations resulting in constitutive activation of the c-MYC oncogene. These results hinted at simple oncogenic mechanisms that would make Burkitt lymphoma paradigmatic for cancers with viral etiology. In reality, the pathogenesis of this tumor is rather complicated with regard to both the contribution of the virus and the involvement of cellular oncogenes. Here, we review the current understanding of the roles of EBV and c-MYC in the pathogenesis of BL and the implications for new therapeutic strategies to treat this lymphoma.

关 键 词：EPSTEIN-BARR病毒 淋巴瘤 C-MYC基因 肿瘤细胞 发病机理 染色体易位 C-MYC 疱疹病毒 

分 类 号：R733.1[医药卫生—肿瘤]