β-tubulinⅢ和Stathmin联合检测在评价多西他赛治疗晚期肺鳞癌疗效中的应用  

Application of joint detection of β-tubulin Ⅲ and stathmin in curative effect evaluation of docetaxel foradvanced squamous cell carcinoma of the lung

作　　者：王秀丽[1] 段惠洁[1] 张国庆[1] 刘春玲[1] 

机构地区：[1]新疆医科大学附属肿瘤医院肺内科,新疆乌鲁木齐830000

出　　处：《实用临床医药杂志》2014年第24期33-36,共4页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11321458)

摘　　要：目的探讨晚期肺鳞癌组织中Ⅲ型β微管蛋白(β-tubulinⅢ)、Stathmin蛋白表达与多西他赛疗效及预后的关系。方法纳入晚期肺鳞癌患者95例,均给予多西他赛联合顺铂方案化疗,观察临床资料、近期疗效、疾病进展时间(TTP)、总生存期(OS),同时用免疫组化SP法检测肺癌组织中β-tubulinⅢ、Stathmin蛋白表达情况。结果β-tubulinⅢ和Stathmin在ECOG评分欠佳、分期较晚的病例中阳性表达率较高。β-tubulinⅢ及Stathmin各自低表达组客观有效率(ORR)、疾病进展时间(TTP)及总生存期(OS)均显著优于各自高表达组(P<0.05或P<0.01)。β-tubulinⅢ、Stathmin均低表达组(双低组)ORR显著高于β-tubulinⅢ、Stathmin均高表达组(双高组)(P<0.01),并高于β-tubulinⅢ高表达组和Stathmin高表达组(P<0.01)。双低组患者的TTP和OS均显著优于β-tubulinⅢ低表达组、Stathmin低表达组和双高组(P<0.01)。结论晚期肺鳞癌中β-tubulinⅢ与Stathmin蛋白表达水平对多西他赛疗效预测及预后评估有一定的临床指导意义,二者联合检测预测价值更高。ABSTRACT： Objective To investigate the relationships between expression of β-tubulin and stathrnin and the effect of docetaxel, as well as prognosis. Methods A total of 95 patients with advanced ,;quamous cell carcinoma of the lung were treated with combined therapy of docetaxel and eisplatin. Short-term effects, time to progression （TTP） and overall survival time （OS） were observed. Expression of β-tubulin Ⅲ and stathmin in carcinoma tissues were detected by immunohistochemistry SP methods. Results β-tubulin Ⅲ and stathmin were observed with high expression in patients with low ECOG socre, late staging. Objective response rate （ORR） , TTP and OS were better in patients with low expression of β - tubulin III or stathmin than in those with high expression （ P 〈 0. 0 5 , P 〈 0.01 ）. ORR was higher in patients with low expression of both β-tubulin Ⅲ and stathmin than those with high expression of both indicators （P 〈0.01 ） , and was higher than those with high expression of β-tubulin Ⅲ or stathmin （P 〈0.01）. TFP and OS in patients with low expression of both indicators were higher than those with low expression ofβ-tubulin Ⅲ or stathmin （ P 〈 0.01 ） and those with high expression of both. Conclusion Joint detection of β-tubulin Ⅲ and stathmin is valuable for estimation of clinical effect of docetaxel and related prognosis.

关 键 词：鳞癌 多西他赛 Ⅲ型β微管蛋白 STATHMIN 

分 类 号：R734.2[医药卫生—肿瘤]