卡巴胆碱联合复合膳食纤维对烫伤休克大鼠肠黏膜血流量的影响  

THE EFFECTS OF CARBACHOL COMBINED WITH COMPOUND DIETARY FIBER ON THE BLOOD FLOW OF INTESTINAL MUCOSA OF SCALDED SHOCK RATS

作　　者：贺瑞新[1] 梁秀敏[1] 王瑞刚[2] 王大力[3] 

机构地区：[1]河北联合大学附属医院药学部,河北省唐山市063000 [2]河北联合大学附属医院神内重症科,河北省唐山市063000 [3]河北联合大学附属医院神经二科,河北省唐山市063000

出　　处：《中国煤炭工业医学杂志》2015年第1期109-112,共4页Chinese Journal of Coal Industry Medicine

基　　金：河北省卫生厅指令性课题(编号:zl20140187)

摘　　要：目的研究卡巴胆碱联合复合膳食纤维对烫伤休克大鼠肠黏膜血流量的影响。方法以30%TBSAⅢ°烫伤Wistar大鼠为动物实验模型,随机分为正常组(N组)、对照组(A组)、实验组(B组),应用激光多普勒分析仪分别在伤后0,2,4,8h监测大鼠腹部经皮氧分压与肠黏膜血流量,并对三组结果予以比较。结果 1烫伤后大鼠腹部经皮氧分压与肠黏膜血流量明显低于正常组,随着复苏进行,逐渐恢复,但未恢复至正常水平;2联合应用卡巴胆碱与膳食纤维,显著提高腹部经皮氧分压,增加肠黏膜血流量。结论卡巴胆碱联合膳食纤维可以改善烫伤大鼠循环状态,早期纠正休克,增加肠黏膜血流。Objective To study the effects of carbachol combined with compound dietary fiber on the blood flow of intestinal mucosa of scalded shock rats. Methods With 30 % TBSA scald Wistar rats as experimen- tal animal model, were randomly divided into normal group （Group N）, control group （Group A） and ex- perimental group （Group 13）. The laser phase Doppler analyzer was applied to monitor respectively abdomi- nal transcutaneous oxygen partial pressure and intestinal mucosal blood flow at 0h, 2h, 4h, 8h after injury in rats, then the results of three groups were compared. Results The abdominal transcutaneous oxygen partial pressure and intestinal mucosal blood flow of scalded rats were significantly lower than those in nor mal group, as the recovery, gradually restored, but did not reach to the normal level. The combined appli- cation of carbachol and compound dietary fiber, improved the abdominal transcutaneous oxygen pressure significantly, increased the intestinal mucous membrane blood flow. Conclusion Carbachol combined with compound dietary fiber can improve the circulation state, early correct shock, increase intestinal mucosal blood flow for scalded rats.

关 键 词：烫伤休克 卡巴胆碱 膳食纤维 肠黏膜 血流量 大鼠 

分 类 号：R364.14[医药卫生—病理学]