Hot spots and future directions of research on the neuroprotective effects of nimodipine  

作　　者：Runhui Li 

机构地区：[1]Department of Neurology,Affiliated Central Hospital of Shenyang Medical College

出　　处：《Neural Regeneration Research》2014年第21期1933-1938,共6页中国神经再生研究（英文版）

基　　金：The National Natural Science Foundation of China;the National Key Basic Research and Development Program(973 Program)of China sponsored 18 of the articles retrieved in our search;The National Commission on Science and Technology Development in Brazil sponsored 6 publications;The Coordenao de Aperfeioamento de Pessoal de Nível Superior(the Brazilian Federal Agency for the Support and Evaluation of Graduate Education)sponsored four publications;the Oak Ridge Institute for Science and Education;NIH Project;Kyung Hee University;German Federal Ministry of Education and Research;Bayer Vital Gmb H Leverkusen each provided funding for two studies(Figure 5)

摘　　要：Calcium antagonists are widely used in the clinical treatment of ischemic cerebrovascular disease because of their vascular and neuroprotective effects. Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tis-sues, thus exerting neuroprotective effects. The aim of the present study was to explore the hot spots and future trends of research on the neuroprotective effects of nimodipine. We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014. The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the infor-mation visualization software CiteSpace III. The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection. According to these co-citation clusters, the research front of nimodipine neuroprotection is the use of randomized controlled trials to study nimodipine intervention of subarachnoid hemorrhage. Using time zone view analysis on hot spots labeled with a key word, the areas of interest in the ifeld of nimodipine neuroprotection are nimodipine pharmacology and therapeutics, blood-brain barrier, trials, and anti-angiospasm.Calcium antagonists are widely used in the clinical treatment of ischemic cerebrovascular disease because of their vascular and neuroprotective effects. Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tis-sues, thus exerting neuroprotective effects. The aim of the present study was to explore the hot spots and future trends of research on the neuroprotective effects of nimodipine. We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014. The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the infor-mation visualization software CiteSpace III. The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection. According to these co-citation clusters, the research front of nimodipine neuroprotection is the use of randomized controlled trials to study nimodipine intervention of subarachnoid hemorrhage. Using time zone view analysis on hot spots labeled with a key word, the areas of interest in the ifeld of nimodipine neuroprotection are nimodipine pharmacology and therapeutics, blood-brain barrier, trials, and anti-angiospasm.

关 键 词：NEUROPROTECTION nerve regeneration NIMODIPINE ischemic cerebrovascular disease Web of Science CiteSpace research fronts development trends scientific mapping VISUALIZATION 

分 类 号：R96[医药卫生—药理学]