三氧化聚合物与波特兰水门汀的理化和生物学性能及其应用  

Physicochemical and biological properties of Portland cement and mineral trioxide aggregate and their applications

作　　者：吴雨鸿[1] 林居红[1] 张红梅[1] 

机构地区：[1]重庆医科大学附属口腔医院儿童口腔科,重庆401147

出　　处：《国际口腔医学杂志》2014年第6期699-702,共4页International Journal of Stomatology

基　　金：重庆市卫生局医学科技计划(2011-2-190)

摘　　要：三氧化聚合物(MTA)和波特兰水门汀(PC)均含有氧化钙,氧化钙与水反应生成氢氧化钙,这样的一个高碱性环境抑制细菌的生长。灰色波特兰水门汀(GPC)中对人体危害的重金属元素铅、砷和铬的质量较白色波特兰水门汀(WPC)和MTA多。根管充填材料的溶解性影响根管充填的封闭性,总体而言,MTA和PC的根尖封闭性能相当。良好的口腔材料应具有适当的凝固时间,在MTA和PC中加入氯化钙或甲酸钙可缩短凝固时间。材料微粒的大小可影响其封闭性、凝固时间、抗压强度和耐磨性能等。WPC的平均粒径大于MTA,其抗压强度小于MTA,但是加有金粉的WPC的抗压强度与MTA相当。MTA和PC皆无细胞毒性和遗传毒性,两者对中国仓鼠卵巢细胞的DNA的影响无差异。MTA和PC对藤黄微球菌、金黄色葡萄球菌和大肠埃希菌等多种微生物有抑菌性能。MTA和PC均可促硬组织矿化,皆可导致牙体牙冠变色,但PC的变色轻于MTA。MTA因凝固时间长、牙体变色、不易取出和价格昂贵等,使其应用受限;而PC则可以作为一种经济的有效的MTA替代材料应用于牙体修复,但其远期疗效还不确定,需要更长时间的随访评估。Mineral trioxide aggregate（MTA） and Portland cement（PC） contain calcium oxide, which reacts with water to form calcium hydroxide and producesa highly alkaline environment that inhibits bacterial growth. Compared with white PC（WPC） and MTA, gray Portland cement（GPC） has high concentrations of harmful heavy metals, namely arsenic, chromium, and lead. The solubility of root-canal filling affects itsability to close. The overall apical closure performances of MTA and PC are relatively similar. Good oral materials should have appropriate setting times. Addition of calcium chloride or calcium formate to MTA and PC shortens their setting time. The particle size of the material also affects its closure, setting time, compressive strength, and abrasion resistance. The average particle size of WPC is greater than that of MTA; however, the compressive strength of the former is lower than that of the latter. When mixed with gold powder, the compressive strength of WPC is similar to that of MTA. MTA and PC are non-toxic and genotoxic, and their toxicities to Chinese hamster ovary cells showno significant difference. Moreover, MTA and PC exhibit antibacterial activities toward Micrococcus luteus, Staphylococcus aureus, Escherichia coli, and other microorganisms. MTA and PC can promote hard tissue mineralization, which can leadto crown discolorations; PC results in lighter colors compared with those observed from MTA. Applications of MTA are limited by its long setting time, tooth discoloration, high-cost, and difficultyof removal. Thus, PC can be an economical alternative to MTA for dental restoration. The long-term effects of this material, however, are still uncertain and require longer assessments.

关 键 词：三氧化聚合物 波特兰水门汀 盖髓术 理化性能 封闭性 细胞毒性 抑菌性 

分 类 号：R783.1[医药卫生—口腔医学]