乳腺癌组织Smo和Gli1蛋白表达的临床意义  

Clinical significance of expressions of Smo and Gli1 of breast carcinoma tissues

作　　者：张兰胜[1] 贾晓民[1] 李彩红[1] 戚迎冬[1] 陈方荟[1] 蒋冠[1] 

机构地区：[1]徐州医学院第二附属医院肿瘤中心,江苏徐州221006

出　　处：《中国校医》2015年第1期78-80,F0003,共4页Chinese Journal of School Doctor

基　　金：2010年江苏省徐州市科技计划项目(XF10C047)

摘　　要：目的探讨Hedgehog信号通路中Smo及Gli1蛋白在乳腺癌组织中的表达及临床意义。方法采用免疫组化法分别检测本院2009.02-2013.02期间79例乳腺癌、68例癌旁正常组织及42例乳腺纤维腺瘤组织中Smo和Gli1蛋白的表达,并分析两者的表达水平与乳腺癌临床病理特征的关系。结果 Smo和Gli1蛋白在乳腺癌组织中的阳性率分别为(73.4%、77.2%),与癌旁正常组织(21.4%、19.0%)及乳腺纤维腺瘤组织(20.6%、23.5%)比较,差异有统计学意义(P=0.023,P=0.045)。Smo和Gli1蛋白表达与患者临床病理分期(P=0.041,P=0.034)及是否腋窝淋巴结转移(P=0.003,P=0.006)有关,而与年龄(P=0.109,P=0.107)及病理类型无关(P=0.078,P=0.083);相关分析显示Smo和Gli1蛋白在乳腺癌组织中的表达呈正相关(r=0.527,P=0.038)。结论Hedgehog信号通路中Smo与Gli1蛋白的异常高表达可能在乳腺癌的发生和发展中起重要作用。Objective To explore the clinical significance of expressions of Smo and Gli1 of breast carcinoma tissues. Methods The protein expressions of Smo and Gli1 were detected by the immunohistochemistry method in 79 cases of human breast cancer,68 normal tissues adjacent to cancer,and 42 breast fibroadenoma tissues. Results The expressions of Smo and Gli1 were significantly higher in breast carcinoma than those in adjacent normal tissues（ 73. 4% vs. 21.4%,77. 2% vs. 19. 0%,P〈0. 05） and breast fibroadenoma（ 73. 4% vs. 20. 6%,77. 2% vs. 23. 5%,P〉0. 05）.The expressions of Smo and Gli1 were correlated with the TNM stage and axillary lymph node metastasis（ P〈0. 05）. The expressions of Smo and Gli1 had no correlation with the age and pathologic type of the patients（ P〈0. 05）. The expressions of Smo was significantly correlated with that of Gli1 in breast cancer（ r = 0. 527,P〈0. 05）. Conclusions The abnormal high expressions of Smo and Gli1 in the Hedgehog signal transduction pathway may play an important role in the occurrence and development of breast carcinoma.

关 键 词：乳腺肿瘤 Hedgenhog蛋白/生理学 SMO蛋白 人 GLI 1蛋白 人 信号传导/生理学 

分 类 号：R735.7[医药卫生—肿瘤]