Environment-responsive drug delivery systems for targeted cancer therapy  

环境响应的智能化递药系统在肿瘤靶向治疗研究的应用(英文)

作　　者：彭春梅[1] 沈洁[1] 陆伟跃[1] 

机构地区：[1]复旦大学药学院智能化递药教育部重点实验室,上海201203

出　　处：《Journal of Chinese Pharmaceutical Sciences》2015年第1期1-11,共11页中国药学（英文版）

基　　金：National Basic Research Program of China(Grant No.973 Program,2013CB932500);National Natural Science Foundation of China(Grant No.81273458);Specialized Research Fund for the Doctoral Program of Higher Education(Grant No.20110071130011)

摘　　要：In order to deliver and/or release anti-cancer therapeutics at the tumor sites, novel environment-responsive drug delivery systems are designed to specifically respond to tumor microenvironment （such as low pH and hypoxia）. Due to their extraordinary advantages, these environment-responsive drug delivery systems can improve antitumor efficacy, and most importantly, they can decrease toxicity associated with the anti-cancer therapeutics. This review highlights different mechanisms of environmentresponsive drug delivery systems and their applications for targeted cancer therapy.环境响应的智能化递药系统可对肿瘤组织特殊生理环境及体外环境变化而发生相应变化,特异地靶向分布于肿瘤组织或在肿瘤组织的特殊生理环境下释放药物,从而可有效改善并提高抗癌药物对肿瘤靶向治疗效果,降低药物毒副作用,已成为近年来肿瘤靶向治疗研究领域的热点之一。本文综述了环境响应的智能化递药系统的靶向机理及其在肿瘤靶向治疗中的应用,以期为新型肿瘤靶向递药系统的开发及其对肿瘤的治疗提供参考。

关 键 词：CANCER Environment-responsive TARGET Smart drug delivery systems 

分 类 号：R94[医药卫生—药剂学]