Biological conduit small gap sleeve bridging method for peripheral nerve injury: regeneration law of nerve fibers in the conduit  

作　　者：Pei-xun Zhang Li-ya A Yu-hui Kou Xiao-feng Yin Feng Xue Na Han Tian-bing Wang Bao-guo Jiang 

机构地区：[1]Department of Trauma and Orthopedics,Peking University People’s Hospital

出　　处：《Neural Regeneration Research》2015年第1期71-78,共8页中国神经再生研究（英文版）

基　　金：supported by grants from the National Program on Key Basic Research Project of China(973 Program),No.2014CB542200;Program for Innovative Research Team in University of Ministry of Education of China,No.IRT1201;the National Natural Science Foundation of China,No.31271284,31171150,81171146,30971526,31100860,31040043,31371210;Program for New Century Excellent Talents in University of Ministry of Education of China,No.BMU20110270

摘　　要：The clinical effects of 2-mm small gap sleeve bridging of the biological conduit to repair periph- eral nerve injury are better than in the traditional epineurium suture, so it is possible to replace the epineurium suture in the treatment of peripheral nerve injury. This study sought to identify the regeneration law of nerve fibers in the biological conduit. A nerve regeneration chamber was constructed in models of sciatic nerve injury using 2-mm small gap sleeve bridging of a biodegradable biological conduit. The results showed that the biological conduit had good his- tocompatibility. Tissue and cell apoptosis in the conduit apparently lessened, and regenerating nerve fibers were common. The degeneration regeneration law of Schwann cells and axons in the conduit was quite different from that in traditional epineurium suture. During the prime period for nerve fiber regeneration （2-8 weeks）, the number of Schwann cells and nerve fibers was higher in both proximal and distal ends, and the effects of the small gap sleeve bridging method were better than those of the traditional epineurium suture. The above results provide an objec- tive and reliable theoretical basis for the clinical application of the biological conduit small gap sleeve bridging method to repair peripheral nerve injury.The clinical effects of 2-mm small gap sleeve bridging of the biological conduit to repair periph- eral nerve injury are better than in the traditional epineurium suture, so it is possible to replace the epineurium suture in the treatment of peripheral nerve injury. This study sought to identify the regeneration law of nerve fibers in the biological conduit. A nerve regeneration chamber was constructed in models of sciatic nerve injury using 2-mm small gap sleeve bridging of a biodegradable biological conduit. The results showed that the biological conduit had good his- tocompatibility. Tissue and cell apoptosis in the conduit apparently lessened, and regenerating nerve fibers were common. The degeneration regeneration law of Schwann cells and axons in the conduit was quite different from that in traditional epineurium suture. During the prime period for nerve fiber regeneration （2-8 weeks）, the number of Schwann cells and nerve fibers was higher in both proximal and distal ends, and the effects of the small gap sleeve bridging method were better than those of the traditional epineurium suture. The above results provide an objec- tive and reliable theoretical basis for the clinical application of the biological conduit small gap sleeve bridging method to repair peripheral nerve injury.

关 键 词：nerve regeneration peripheral nerve small gap AXONS Schwann cells repair injury biological conduit NSFC grants neural regeneration 

分 类 号：R745[医药卫生—神经病学与精神病学]