染色体平衡易位携带者引起不良孕育的临床分析  

Clinical Analysis of the Relationship between Balanced Chromosomal Translocation and Abnormal Pregnancy

作　　者：沈红霞[1] 尹坤[1] 

机构地区：[1]大理学院附属医院,云南大理671000

出　　处：《大理学院学报（综合版）》2015年第2期41-43,共3页Journal of Dali University

摘　　要：目的:通过对2 450例有自然流产、死胎、畸胎、少精等不良孕育史的患者的染色体结果调查,探讨平衡易位与不良孕育史的关系。方法:取外周血进行淋巴细胞培养,染色体G显带分析。结果:2 450例患者中检出染色体平衡易位22例(罗伯逊易位3例),占0.90%。患者表现为自然流产、死胎、畸形儿、少精等不良孕育史。结论:染色体平衡易位是导致患者不良孕育史的重要原因之一。对这类人群进行遗传优生和产前诊断及辅助生殖指导等有针对性的检查和临床干预是非常必要的。Objective： To investigate 2 450 patients＇ chromosomes with a history of abnormal pregnancy such as spontaneous abortion, fetal death, teratism, and oligospermia and to explore the relationship between balanced chromosomal translocation and abnormal pregnancy. Methods： Chromosomal analysis was made by peripheral lymphocytes culture and G-banding. Results： 22 cases of balanced translocation were discovered（3 cases of robertsonian translocation）accounting for 0.90%. Spontaneous abortion, fetal death, teratism, and oligospermia were main manifestations of abnormal pregnancy. Conclusion： Balanced chromosomal translocation was a major reason for abnormal pregnancy. Examination of heredity and prepotency, prenatal diagnosis, guidance on assisted production were necessary for balanced chromosomal translocation carriers.

关 键 词：不良孕育史 遗传咨询 染色体 平衡易位 

分 类 号：R394[医药卫生—医学遗传学]