一种制备头孢地尼的新方法  

A New Method for Preparing Cefdinir

作　　者：付德才[1] 陈兴贺[1] 石少龙[1] 郑美玲[1] 谷明明[1] 

机构地区：[1]河北科技大学化学与制药工程学院,石家庄050018

出　　处：《国外医药（抗生素分册）》2015年第2期68-70,共3页World Notes on Antibiotics

摘　　要：目的探索头孢地尼的制备方法。方法三苯甲基头孢地尼甲磺酸N,N-二甲基乙酰胺复合物为原料在磷酸和硫酸的乙腈溶液中脱除三苯甲基形成新的三元复合物;精制得到头孢地尼。结果目标化合物经过1H-NMR和13C-NMR确证,且含量在98%以上,纯度高于99%,E-构型异构体含量小于0.1%,产品质量符合2010版药典标准。结论操作简单,收率高,易于产业化。Objective Explore the preparation method of cefdinir. Methods The cefdinir was obtained by refinement of the new complex of cefdinir which was prepared by reaction of three element complex of trityl cefdinir, methanesulfonic acid and DMAc with mixture of phosphoric acid and sulfuric acid in the solution of acetonitrile. Results The chemical structure of the target compound was cofirmed by 1H-NMR and 13C-NMR. The content of target compound was over 98%, purity was over 99% （HPLC） and content of isomers was less than 0.1%.The quality of product conforms to the 2010 Chinese Pharmcopoeia standards. Conclusions A more reasonable operational path for the manufacturing process of cefdinir was provided by this experiment.

关 键 词：头孢地尼三元复合物 头孢地尼 合成 

分 类 号：R978.11[医药卫生—药品]