Regeneration across Metazoan Phylogeny:Lessons from Model Organisms  

作　　者：Qiao Li Hao Yang Tao P.Zhong 

机构地区：[1]State Key Laboratory of Genetic Engineering,Department of Genetics,Fudan University School of Life Science [2]Department of Medicine,Vanderbilt University School of Medicine

出　　处：《Journal of Genetics and Genomics》2015年第2期57-70,共14页遗传学报（英文版）

基　　金：supported in part by the grants from the National Basic Research Program of China (Nos.MOST945300 and MOST944500 to TPZ);the National Natural Science Foundation of China (No.31172173 to TPZ)

摘　　要：Comprehending the diversity of the regenerative potential across metazoan phylogeny represents a fundamental challenge in biology. Invertebrates like Hydra and planarians exhibit amazing feats of regeneration, in which an entire organism can be restored t^om minute body segments. Vertebrates like teleost fish and amphibians can also regrow large sections of the body. While this regenerative capacity is greatly attenuated in mammals, there are portions of major organs that remain regenerative. Regardless of the extent, there are common basic strategies to regeneration, including activation of adult stem cells and proliferation of differentiated cells. Here, we discuss the cellular features and molecular mechanisms that are involved in regeneration in different model organisms, including 14ydra, planarians, zebrafish and newts as well as in several mammalian organs.Comprehending the diversity of the regenerative potential across metazoan phylogeny represents a fundamental challenge in biology. Invertebrates like Hydra and planarians exhibit amazing feats of regeneration, in which an entire organism can be restored t^om minute body segments. Vertebrates like teleost fish and amphibians can also regrow large sections of the body. While this regenerative capacity is greatly attenuated in mammals, there are portions of major organs that remain regenerative. Regardless of the extent, there are common basic strategies to regeneration, including activation of adult stem cells and proliferation of differentiated cells. Here, we discuss the cellular features and molecular mechanisms that are involved in regeneration in different model organisms, including 14ydra, planarians, zebrafish and newts as well as in several mammalian organs.

关 键 词：REGENERATION Stem cells DEDIFFERENTIATION Model organisms Mammalian organs Tissue repair 

分 类 号：Q951.3[生物学—动物学]