食用菌活性成分抗肿瘤作用的研究进展  

Advance in Antitumor Mechanism of Bioactive Compounds in Edible Mushrooms

作　　者：陈开旭[1] 王为兰[1] 刘军[1] 张富春[1] 郑秀芬[1,2,3] 

机构地区：[1]新疆生物资源基因工程重点实验室新疆大学生命科学与技术学院,乌鲁木齐830046 [2]加拿大西安大略大学病理科 [3]加拿大劳森健康研究所

出　　处：《生物技术通报》2015年第3期35-42,共8页Biotechnology Bulletin

基　　金：新疆自治区动物学重点学科资助项目(2011001);新疆大学天山学者特聘教授科研项目资金;新疆生物资源基因工程重点实验室开放课题(XJDX0201-2014-08)

摘　　要：食用菌因药食两用的特点被广泛研究,具有提升机体免疫,阻止和防御疾病的功能作用。不同食用菌中所含的生物活性组分不同,主要有:多糖类、蛋白类、萜类、生物碱类等,这些组分具有抗氧化、抗肿瘤、免疫调节、抗炎症反应、抗心血管疾病、抗细菌、抗辐射及抗糖尿病等功效,其中抗肿瘤作用研究居多,研究发现其分子作用机制主要通过调控细胞信号通路中相关因子表达水平抑制肿瘤细胞增殖,诱导细胞凋亡的,这为开发天然无毒性肿瘤药物制剂奠定了理论基础。针对食用菌不同生物活性组分抗肿瘤分子机制的最新研究进展展开简要综述。Edible mushrooms have been globally consumed for centuries to promote human health, prevent and treat human diseases. In different types of edible mushrooms, there are distinct bioactive compounds, mainly consisted of polysaccharide, protein, terpenoids, alkaloids and others substances. They possess many medicinal effects such as anti-cancer, anti-cardiovascular diseases, and anti-diabetes, etc. Mushroom bioactive constituents have been found to have anti-cancer effects against several major cancer types. It is reported that edible mushrooms exert an anti-cancer effect through regulating the expression level of relevant factors in cell signaling pathway, which leads to inhibition of cell proliferation and induction of cellular apoptosis. These findings may provide theoretical basis for utilizing edible mushrooms as potential natural and non-toxic antitumor agents. This paper provided a brief review on the research progress in antitumor mechanism of different bioactive compounds in edible mushrooms..

关 键 词：食用菌 活性成分 抗肿瘤 

分 类 号：R285[医药卫生—中药学]