儿童骨痛-活动障碍-反复骨折  

Child bone pain-physical inactivity-repeated fractures

作　　者：马豆豆 夏维波[1] 余卫[2] 范志宏[3] 刘怡[1] 吕芳[1] 周沛然[1] 姜艳[1] 王鸥[1] 邢小平[1] 李梅[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院内分泌科,卫生部内分泌重点实验室,北京100730 [2]中国医学科学院北京协和医学院北京协和医院放射科,北京100730 [3]山西医科大学第二附属医院内分泌科,太原市030001

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2015年第1期53-57,共5页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家自然科学基金(81100623);国家临床重点专科课题(WBYZ 2011-873)

摘　　要：对1例表现为进行性加重的骨骼疼痛、活动障碍、反复骨折的9岁男童进行细致诊断及鉴别诊断,初步明确患者罹患严重骨质疏松,合并骨质破坏。进一步行内分泌疾病、肿瘤性疾病、遗传性骨病的深入检查,尽管患者外周血象及血涂片正常,但骨髓穿刺及活检结果明确诊断为急性淋巴细胞白血病诱发的骨病。剖析本例患儿的诊断过程,有助于提高临床医师对骨骼疾病鉴别诊断水平。We completed a detailed diagnosis and differential diagnosis in a 9-year-old boy with bone pain and re-peated fractures .He suffered from severe osteoporosis and bone destruction .Further examinations were completed , such as endocrine diseases , tumor, genetic bone diseases and so on .Although routine blood test and blood smear were normal , the diagnosis of acute lymphoblastic leukemia （ ALL） was confirmed finally on the basis of bone marrow aspiration .Step-by-step analysis of the diagnosis of this patient is helpful to improve the differential diagnosis of complicated bone diseases .

关 键 词：骨痛 反复骨折 白血病 

分 类 号：R733[医药卫生—肿瘤]