Caco-2细胞模型预测活性物质吸收代谢的研究进展  

Research Progress of Caco-2 Models in Absorption and Metabolism of Active Substance

作　　者：黄海智[1] 陈健乐[1] 程焕[1] 陈荣荣 田金虎[1] 叶兴乾[1] 

机构地区：[1]浙江大学生物系统工程与食品科学学院馥莉食品研究院浙江省农产品加工技术研究重点实验室,杭州310058 [2]杭州艾菲曼普香精香料有限公司,杭州311215

出　　处：《中国食品学报》2015年第1期164-172,共9页Journal of Chinese Institute Of Food Science and Technology

基　　金：国家科技支撑计划项目(2012BAD31B06);浙江省重大项目(2012C12011-2)

摘　　要：Caco-2细胞单层作为一种重要的肠吸收模型,现已广泛应用到食品活性物质的研究中。本文中比较了Caco-2细胞模型吸收和肠上皮吸收的异同点,讨论此模型预测的可靠性;同时总结使用Caco-2细胞模型在研究活性物质(如维生素、类胡萝卜素、花色苷、原花色素和黄酮类化合物等)吸收、代谢机制方面的进展情况。Caco-2 cell monolayers have been widely used in the research of active substance as a model of intestinal absorption. In this review, the absorption of Caco-2 cell monolayers and intestinalepithelium were compared and the reliability of Caco-2 models was discussed. In addition, this paper summarized the research progress of Caco-2 models in absorption and metabolism of active substance such as vitamin, carotenoids, anthocyanins, proanthocyanidins and flavonoids.

关 键 词：CACO-2细胞模型 活性物质 吸收 代谢 

分 类 号：Q25[生物学—细胞生物学]