二氢黄酮类化合物的合成研究进展  

Reviews on flavanone compounds synthesis research

作　　者：梁海[1,2] 向卓[2] 张学辉[2] 吴久鸿[2] 

机构地区：[1]安徽医科大学药学院,安徽合肥230032 [2]解放军306医院药学部,北京100101

出　　处：《药学实践杂志》2015年第2期97-101,130,共6页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金项目(No.81072546)

摘　　要：综述二氢黄酮类化合物的合成研究进展,总结已报道的各种类型的二氢黄酮合成方法,为二氢黄酮类新药研发提供方法学支持。合成方法包括:查尔酮环合、Friedel-Crafts反应、Knoevenagel缩合和Hoesch单酰基化反应,以及二氢黄酮的不对称合成,并简要介绍无溶剂合成二氢黄酮等"绿色"化学方法。Research progress of flavanone compounds synthesis was reviewed ,various types of synthesis methods of fla‐vanone compounds were summarized ,and methodological support for flavanone compounds in new drug research and develop‐ment was provided .Research progress in synthesis of flavanone compounds includes chalcone cyclization ,Friedel‐Crafts reac‐tion ,Knoevenagel condensation ,Hoesch single acetoxylation ,and asymmetric synthesis of flavanone compounds .Solvent‐free synthesis of flavanone compounds and other green chemistry methods were also introduced .

关 键 词：二氢黄酮类化合物 查尔酮 环合 合成 

分 类 号：R916[医药卫生—药学]