Not just a sponge: new functions of circular RNAs discovered  

作　　者：WANG ZeFeng 

机构地区：[1]CAS-MPG Partner Institute of Computational Biology

出　　处：《Science China(Life Sciences)》2015年第4期407-408,共2页中国科学（生命科学英文版）

摘　　要：One of the most exciting findings in RNA biology is the discovery of numerous circular RNAs （circRNA） in mammalian genome. Once being considered as low abundance splicing byproducts, circRNAs are surprisingly abundant and can be generated by multiple pathways. The majority of circRNAs are generated from the RNA backsplicing in which an upstream 3＇ splicing site （ss） is joined with a downstream 5＇ ss. Several groups have independently demonstrated that the complementary paring of intronic sequences is sufficient to promote the biogenesis of circRNA via backsplicing. In addition, intronic circRNAs can also be generated through partial degradation of lariat RNAs that are splicing byproduct.One of the most exciting findings in RNA biology is the discovery of numerous circular RNAs(circ RNA)in mammalian genome.Once being considered as low abundance splicing byproducts,circ RNAs are surprisingly

关 键 词：RNA 圆形 内含子序列 海绵 剪接位点 动物基因组 生物合成 副产品 

分 类 号：Q522[生物学—生物化学] TU375[建筑科学—结构工程]