小麦肽对模拟高原训练大鼠骨骼肌蛋白代谢影响及机制研究  

Study on the effects of wheat peptide on skeletal muscle protein metabolism in rats during simulated altitude training and its mechanism

作　　者：柏海平[1] 

机构地区：[1]石家庄学院体育系,河北石家庄050035

出　　处：《食品工业科技》2015年第8期348-350,355,共4页Science and Technology of Food Industry

摘　　要：目的:探讨小麦肽对模拟高原训练大鼠骨骼肌代谢的影响,以及可能的机制。方法:75只雄性SD大鼠随机分为正常对照组(A组)、低氧对照组(B组)、运动训练组(C组)、低氧+运动训练组(D组)、低氧+运动训练+补充小麦肽组(E组),每组15只,C组、D组和E组进行无负重游泳9周,E组大鼠于每次训练后灌服小麦肽溶液。实验结束后,检测骨骼肌总蛋白(Pro)、肌球蛋白(Myo)、胰岛素样生长因子-1(IGF-1)。结果:与A组相比,B组大鼠骨骼肌总蛋白(Pro)和肌球蛋白(Myo)含量均显著降低,C组大鼠骨骼肌Pro含量无差异,而Myo含量则显著降低;E组大鼠骨骼肌Pro和Myo含量均高于B组和C组。与A组相比,B组和C组大鼠骨骼肌和血清中胰岛素样生长因子-1(IGF-1)含量均降低;E组大鼠骨骼肌和血清中IGF-1含量均高于B组和C组。结论:补充小麦肽可有效降低模拟高原训练对大鼠骨骼肌蛋白的影响,可能通过促进IGF-1分泌而加速骨骼肌蛋白的合成代谢。Objective：To investigate the effects of wheat peptide on skeletal muscle protein metabolism in rats during simulated altitude training and its mechanism. Methods：75 male SD rats were randomly divided into normal control group（group A）,hypoxia group（group B）,exercise training group（group C）,hypoxic exercise training group（group D）,hypoxic exercise training ＋ add wheat peptide group（group E）,each group had 15 rats. Rats in group C,group D and group E were undergoing no load swimming for 9 weeks. Rats in group E were fed wheat peptide solution after each train. After the experiment,the skeletal muscle total protein（Pro）,myosin（Myo） and insulin-like growth factor-1（IGF-1） were detected. Results：Compared with group A,the total protein（Pro） and myosin（Myo） of rat skeletal muscle in group B were significantly reduced,and the Pro in group C showed no difference,while Myo content was significantly reduced. The Pro and Myo contents in skeletal muscle of rats in group E were higher than hypoxic control group and exercise training group. Compared with group A,the insulin growth factor-l（IGF-1） levels in rat skeletal muscle and serum in group B and group C were reduced. The IGF-1 levels in rat skeletal muscle and serum in group E were higher than group B and group C. Conclusion：Supplying of wheat peptide in rats could effectively reduce the effect of simulated altitude training on skeletal muscle protein. It might promote the secretion of IGF-1 to accelerate the anabolism of skeletal muscle protein.

关 键 词：小麦肽 大鼠 模拟高原训练 骨骼肌蛋白 机制 

分 类 号：TS201.1[轻工技术与工程—食品科学]