Prefrontal cortical dopamine from an evolutionary perspective  

作　　者：Young-A Lee Yukiori Goto 

机构地区：[1]Department of Food Science and Nutrition, Catholic University of Daegu [2]Kyoto University Primate Research Institute

出　　处：《Neuroscience Bulletin》2015年第2期164-174,共11页神经科学通报（英文版）

基　　金：supported by Kyoto University;the Ito Chubei Foundation;the Ichiro Kanehara Foundation;the Institute of Life & Seizon, Japan

摘　　要：In this article, we propose the hypothesis that the prefrontal cortex （PFC） acquired neotenic development as a consequence of mesocortical dopamine （DA） innervation, which in turn drove evolution of the PFC into becoming a complex functional system. Accordingly, from the evolutionary perspective, decreased DA signaling in the PFC associated with such adverse conditions as chronic stress may be considered as an environmental adaptation strategy. Psychiatric disorders such as schizophrenia and attention deficit/hyperactivity disorder may also be understood as environmental adaptation or a by-product of such a process that has emerged through evolution in humans. To investigate the evolutionary perspective of DA signaling in the PFC, domestic animals such as dogs may be a useful model.In this article, we propose the hypothesis that the prefrontal cortex （PFC） acquired neotenic development as a consequence of mesocortical dopamine （DA） innervation, which in turn drove evolution of the PFC into becoming a complex functional system. Accordingly, from the evolutionary perspective, decreased DA signaling in the PFC associated with such adverse conditions as chronic stress may be considered as an environmental adaptation strategy. Psychiatric disorders such as schizophrenia and attention deficit/hyperactivity disorder may also be understood as environmental adaptation or a by-product of such a process that has emerged through evolution in humans. To investigate the evolutionary perspective of DA signaling in the PFC, domestic animals such as dogs may be a useful model.

关 键 词：NEURODEVELOPMENT NEOTENY psychiatric disorder stress animal model synaptic plasticity environmental adaptation 

分 类 号：R338[医药卫生—人体生理学]