6-三氟甲基-3,4,5,6-四氢嘧啶-2(1H)-(硫)酮类化合物的合成及其除草活性  

Synthesis and Herbicidal Activities of 6-Trifluoromethyl-3,4,5,6-tetrahydropyrimidin-2(1H)-(thi)one Derivatives

作　　者：李公春[1] 张洪浩[1] 朱凤祥[1] 吴长增[1] 

机构地区：[1]许昌学院化学化工学院,河南许昌461000

出　　处：《湖北农业科学》2015年第2期352-354,共3页Hubei Agricultural Sciences

基　　金：河南省重点科技攻关项目(132102210263);河南省科技计划项目(122102210426);河南省教育厅自然科学研究项目(2011A150025)

摘　　要：以取代苯甲醛、三氟乙酰乙酸乙酯和脲(或硫脲)为原料,以氨基磺酸作催化剂,以无水乙醇为溶剂,在加热搅拌条件下回流反应3 h,得到6个6-三氟甲基-3,4,5,6-四氢嘧啶-2(1H)-(硫)酮类化合物。初步生物活性测试表明该类化合物具有一定的除草活性,但活性不强,在浓度100μg/m L时,最佳抑制效果是化合物d对油菜根长生长抑制率为45%。Six derivatives of 6-trifluoromethyl-3,4,5,6-tetrahydropyrimidin-2（1H）-（thi）one were synthesized by substituted benzaldehyde, ethyl 4,4,4-trifluoroacetoacetate and urea（or thiurea）, with catalyst of sulfamicacid, solvent of ethanol,refluxing for 3 h under the condition of stirring. The preliminary bioassay results showed that compounds had herbicidal activities, but the herbicidal activities were not strong. When compounds exhibited herbicidal activities of 45% against Brassica napus at 100 μg/m L, the effect was best.

关 键 词：6-三氟甲基-3 4 5 6-四氢嘧啶-2(1H)-(硫)酮 合成 除草活性 

分 类 号：O626.4[理学—有机化学] S482.4[理学—化学]