4’-甲氧基-2’-羟基查尔酮及衍生物的合成与活性  

Synthesis and Activity Detection of 4'-Methoxy-2'-Hydroxy Chalcone and its Derivatives

作　　者：郑高亮[1,2] 卢俊[1,2] 余心哲 郁建平[1,2] 

机构地区：[1]贵州大学药学院,贵州贵阳550025 [2]贵州大学生化营养研究所,贵州贵阳550025

出　　处：《山地农业生物学报》2015年第1期47-51,共5页Journal of Mountain Agriculture and Biology

基　　金：贵州省科技厅省地合作项目:梵净山天然中兽药研发关键技术研究及贵州省科技厅农业攻关[黔科合NY(2011)3094号];贵州省教育厅制药工程专业综合改革(2013)项目资助

摘　　要：以对甲氧基苯乙酮和苯甲醛衍生物为原料,在无水乙醇为溶剂的条件下,采用浓度为2.5mol/L的Na OH溶液为催化剂,经aldol缩合获得了8种查尔酮衍生物,采用1HNMR、13CNMR、MS对其进行了结构表征。采用MTT法测定了2种查尔酮衍生物的乳腺癌MDA231细胞抑制活性,并使用了原料作为对照组,实验结果表明对照检查几乎没抗乳腺癌MAD231细胞活性,实验组有一定抗乳腺癌MAD231细胞活性,查尔酮及衍生物有作为抗癌药物的潜在价值。With methoxy acetophenone and benzaldehyde derivatives as raw materials,anhydrous ethanol as solvent,and 2. 5 mol / L Na OH solution as catalyst,eight chalcone derivatives were synthesized by the aldol condensation,and their structures were characterized by1H-NMR,13 C NMR and MS. Activity of two chalcone derivatives for inhibiting breast cancer MDA231 cells were determined by MTT method. The results showed that two chalcone derivatives somewhat had practical activity of anti-breast cancer MAD231 cells,conversely,the raw materials had no anti-breast cancer effect,indicating that chalcone and its derivatives were promising for antitumor drug exploitation

关 键 词：查尔酮衍生物 aldol缩合 抗癌活性 

分 类 号：R914.1[医药卫生—药物化学]