胶质母细胞瘤经典亚型特征性基因变异的研究进展  

Advanced research on characteristics of the classical subtype of human glioblastoma

作　　者：刘恩瑞 任欢[1] 赵宇[1] 苏君[2] 

机构地区：[1]哈尔滨医科大学免疫教研室,哈尔滨150081 [2]哈尔滨医科大学附属肿瘤医院神经外科

出　　处：《实用肿瘤学杂志》2015年第2期136-139,共4页Practical Oncology Journal

基　　金：国家自然科学基金重大项目培育项目（NSFC91229112）;黑龙江省科技攻关项目（GCl2C303-1）

摘　　要：目的：胶质母细胞瘤（ Glioblastoma，GBM）是颅内最常见的原发恶性肿瘤，其恶性程度高、侵袭能力强、预后差。近年来随着生物学技术的发展，对GBM的理解也从病理学诊断逐步转向分子病理机制的研究。根据基因表达和DNA甲基化的模式将原发性GBM分为经典型、间质型、前神经元型和神经元型四种亚型。这些分子分型与胶质母细胞瘤的生物学特性密切相关。本文简要介绍了原发胶质母细胞瘤的分子分型，重点关注经典型GBM中EGFR、PTEN、PI3K和CDKN2A四种特征性基因的变异情况，并且对经典型胶质母细胞瘤的治疗策略进行了探讨。Glioblastoma（GBM）is one of the most common primary intracranial tumor that has high de-gree of malignancy ,invasive ability and a fatal prognosis .In recent years ,with the development of modern technol-ogy in biomedical sciences ,the understanding on GBM has developed gradually from pathological diagnosis to mo -lecular classifications ,which is based on the molecular characteristics of genetic signatures .Based on gene expres-sion and DNA methylation patterns , primary glioblastoma is divided into four subtypes , including the classical , neural,proneural and mesenchymal .These molecular classifications are closely relevant to the biological charac-teristics of glioblastoma .This review briefly introduces the molecular classifications of primary glioblastoma , but mainly focuses on the changes of the major genetic EGFR ,PTEN and PI3K,CDKN2A in the classical subtype of GBM,and discusses the treatment strategies for primary glioblastoma .

关 键 词：胶质母细胞瘤 分子分型 基因变异 经典型胶质母细胞瘤 分子靶向治疗 

分 类 号：R739.4[医药卫生—肿瘤]