NF2/Merlin在原发性肝癌中的表达及临床意义研究  

Study on the expression of neurofibromatosis 2 gene and its clinical significance in primary liver cancer

作　　者：赵璋[1] 吕婷霞 张宁[1] 王岩[1] 何肖敏[1] 张蓓[1] 黄坚[1] 

机构地区：[1]首都医科大学附属北京友谊医院肝病中心肝硬化转化医学北京市重点实验室北京市临床医学研究所实验中心,北京100050

出　　处：《临床和实验医学杂志》2015年第7期535-538,共4页Journal of Clinical and Experimental Medicine

基　　金：王宝恩肝纤维化基金(20100013);教育部留学回国人员科研启动基金(2011年第41批)

摘　　要：目的研究NF2/Merlin在原发性肝癌中的表达及临床意义。方法免疫组织化学法测定94例肝细胞癌(HCC)和37例肝内胆管细胞癌(ICC)的Merlin表达,并对癌组织中的表达与其临床病理的关系进行分析。结果Merlin蛋白在癌组织中的表达高于癌旁组织。HCC中Merlin蛋白高表达率为20.2%,ICC中Merlin蛋白高表达率为45.9%。在HCC中,Merlin蛋白的表达高低与肿瘤的分期、HBV感染和肿瘤细胞的分化程度均无关,但在ICC中Merlin蛋白的表达高低与肿瘤细胞的分化程度相关。结论 NF2基因的表达可能与原发性肝癌的发生相关。Objective To determine the expression of NF2 gene and its clinical significance in primary liver cancer（ PLC）. Methods The expression of NF2 gene in 94 cases of hepatocellular carcinoma（ HCC） and 37 cases of intrahepatic cholangiocellular carcinoma（ ICC） had been detected by immunohistochemical method. The relationship between the expression of NF2 gene and clinico- pathological characteristics had been analyzed. Results The rates of high expression were 20. 2% and 45. 9% in HCC and ICC respectively. The expression of Merlin in tumor tissue was higher than that of adjacent non- tumor tissue. There was no correlation between the expression of NF2 gene and clinico- pathological characteristics in HCC,but there was correlation between the expression of NF2 gene and differentiation of tumor cells in ICC. Conclusion The expression of NF2 gene may associate with the development and progress of PLC.

关 键 词：原发性肝癌 NF2基因 MERLIN蛋白 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]