Effects of simvastatin on activities of endogenous antioxidant enzymes and angiotensin-converting enzyme in rat myocardium with pressure-overload cardiac hypertrophy  

辛伐他汀对压力超负荷心肌肥厚大鼠心肌内源性抗氧化酶及血管紧张素转化酶活性的影响

作　　者：罗健东[1] 张维文[1] 张贵平[1] 钟蓓华[1] 区慧坚[1] 

机构地区：[1]广州医学院药理教研室,广州市中国510182

出　　处：《Acta Pharmacologica Sinica》2002年第2期124-128,共5页中国药理学报（英文版）

基　　金：Project supported by Education Ministry of China (№ 0110-B042) and Education Committee of Guangzhou.

摘　　要：To investigate effects of simvastatin (Sim) on the activities of antioxidant enzymes and angiotensin-converting enzyme in rat myocardium with pressure-overload cardiac hypertrophy. METHODS-. Left ventricular hypertrophy (LVH) was induced by partly constricting rat abdominal aorta between the left and right renal artery. Rats were given ig Sim 1.8 and 3.6 mg ·kg-1·d-1 for 8 weeks following 6 weeks aortic constriction. Activities of antioxidant enzymes and angiotensin-converting enzyme, and lipid peroxidation of left ventricular ( LV ) tissue were determined. RESULTS: Contents of angiotensin Ⅱ and thiobarbi-turic acid reactive substances (TBARS), and activity of ACE in LVH group ( n = 8) were increased by 163 % , 90 % , and 130 % , respectively ( P < 0.01) compared with sham-operated group ( n = 7), and were decreased by 30 % , 37 % , and 51 % , respectively ( P < 0.01) in high dosage Sim treatment group ( n = 9) compared with LVH group. Activities of catalase and glutathione peroxidase of LV tissue in LVH group were decreased by 29 % and 23 % ( P < 0.01) compared with sham-operated group, and were increased by 32 % and 22 % (P < 0.01 ) in high dosage Sim treatment group compared with LVH group. Activity of Cu, Zn-superoxide dismutase (SOD) of LV tissue was increased by 33 % in LVH group compared with sham-operated group. Sim treatment did not significantly affect activity of Cu, Zn- SOD. CONCLUSION: Alteration of redoxstatus in myocardium is associated with cardiachypertrophy and inhibitory effects of Sim on cardiachypertrophy in rats model might be linked to its antioxidant effects.目的:研究辛伐他汀对压力超负荷心肌肥厚大鼠心肌内源性抗氧化酶及血管紧张素转化酶活性的影响.方法:在左右肾动脉之间部分结扎腹主动脉诱导左心室肥厚(LVH).6周后,大鼠ig辛伐他汀1.8和3.6mg·kg^(-1)·d^(-1)8周,然后测定左心室组织内源性抗氧化酶和血管紧张素转化酶(ACE)活性以及脂质过氧化物(TBARS)含量.结果:LVH组(n=8)大鼠左心室组织血管紧张素Ⅱ(Ang Ⅱ)和TBARS含量、ACE及Cu,Zn-超氧化物歧化酶(SOD)活性分别比假手术组(n=7)大鼠增加163％、90％、130％和33％(P<0.01),而过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)的活性则分别比假手术组大鼠减少29％和23％(P<0.01).3.6mg·kg^(-1)·d^(-1)辛代他汀处理的大鼠(n=9)Ang Ⅱ、TBARS含量及ACE活性比LVH组大鼠分别减少30％,37％和51％,而CAT和GSH-Px的活性比LVH组大鼠分别增加32％和22％(P<0.01).辛伐他汀对SOD活性没有明显的影响.结论:心肌内抗氧化酶活性的变化与压力超负荷性心肌肥厚的形成和发展有关.辛伐他汀对大鼠心肌肥厚的抑制作用可能与其抗氧化作用有关.

关 键 词：angiotensin Ⅱ ANTIOXIDANTS CARDIOMEGALY peptidyl-dipeptidase A SIMVASTATIN 

分 类 号：R96[医药卫生—药理学]