Prazosin:a potential new management tool for iatrogenic autonomic dysreflexia in individuals with spinal cord injury?  

作　　者：Mei M.Z.Zheng Aaron A.Phillips Stacy L.Elliott Andrei V.Krassioukov 

机构地区：[1]Experimental Medicine Program,Faculty of Medicine,University of British Columbia,Vancouver V5Z 1M9,Canada [2]International Collaboration on Repair Discoveries (ICORD),University of British Columbia,Vancouver V5Z 1M9,Canada [3]Centre for Heart,Lung,and Vascular Health,Faculty of Health and Social Development,University of British Columbia,Kelowna V1V 1V7,Canada [4]Department of Psychiatry,University of British Columbia,ancouver V6T 2A1,Canada [5]Department of and Urologic Sciences,University of British Columbia,Vancouver V5Z 1M9,Canada [6]Vancouver Sperm Retrieval Clinic,Vancouver Coastal Health Authority,Vancouver V5Z 1M9,Canada [7]G.F.Strong Rehabilitation Center,Sexual Health Rehabilitation Service,Vancouver V5Z 2G9,Canada [8]Division of Physical Medicine and Rehabilitation,Department of Medicine,University of British Columbia,Vancouver V5Z 2G9,Canada

出　　处：《Neural Regeneration Research》2015年第4期557-558,共2页中国神经再生研究（英文版）

基　　金：AAP is supported by the Heart and Stroke Foundation of Canada;the Michael Smith Foundation for Health Research;AVK is supported by the Paralyzed Veterans of America;the Craig Neilson Foundation;the Canadian Institute of Health Research;the Heart and Stroke Foundation of Canada

摘　　要：Spinal cord injury （SCI） is a devastating condition that not only results in a loss of motor functions but also severe autonomic dysfunctions （Krassioukov and Claydon, 2006）. Autonomic dysreflexia （AD） is a life threatening episode of tran- sient hypertension that occurs up to 30x/day （1 Ix/day on average） in those with cervical or high thoracic SCI （Hubli et al., 2015）. Most common triggers of AD are from stimuli such as a full bowel and/or bladder, or sexual arousal （Teasell et al., 2000）. Penile vibrostimulation （PVS） is a clinical pro- cedure for sperm retrieval used for the purpose of family planning or fertility assessment that unfortunately iatrogenically induces episodes of AD （Elliott, 2006）. Recently, we published a clinical trial highlighting that prazosin may be a viable option for treating AD secondary to PVS （Phillips et al., 2014）.Spinal cord injury （SCI） is a devastating condition that not only results in a loss of motor functions but also severe autonomic dysfunctions （Krassioukov and Claydon, 2006）. Autonomic dysreflexia （AD） is a life threatening episode of tran- sient hypertension that occurs up to 30x/day （1 Ix/day on average） in those with cervical or high thoracic SCI （Hubli et al., 2015）. Most common triggers of AD are from stimuli such as a full bowel and/or bladder, or sexual arousal （Teasell et al., 2000）. Penile vibrostimulation （PVS） is a clinical pro- cedure for sperm retrieval used for the purpose of family planning or fertility assessment that unfortunately iatrogenically induces episodes of AD （Elliott, 2006）. Recently, we published a clinical trial highlighting that prazosin may be a viable option for treating AD secondary to PVS （Phillips et al., 2014）.

关 键 词：PRAZOSIN SCI AD DBP 

分 类 号：R651.2[医药卫生—外科学]