慢性胰腺炎患者血液免疫指标的检测和分析  

Detection and analysis of blood immune parameters in patients with chronic pancreatitis

作　　者：郑兆泓 赵九龙[1] 杜婷婷[1] 胡良皞[1] 廖专[1] 叶博[1] 李白容[1] 季钧淘[1] 王丹[1] 林金欢 李兆申[1] 

机构地区：[1]第二军医大学长海医院消化内科,上海200433

出　　处：《中华胰腺病杂志》2015年第2期93-96,共4页Chinese Journal of Pancreatology

摘　　要：目的 检测慢性胰腺炎（CP）患者各项血液自身免疫指标的阳性率,探讨其临床价值.方法 检测上海长海医院消化科就诊的409例CP患者的抗可提取性核抗原抗体（抗ENA抗体）、抗胞浆型中性粒细胞抗体、抗β2-糖蛋白1抗体（anti-β2-GPI）、抗心磷脂抗体（ACA）、抗单链-DNA抗体等25项血清相关自身免疫指标,并与系统检索的Pubmed数据库内相关文献的健康人群阳性率进行比较.结果 409例CP患者中仅检出anti-β2-GPI、ACA、抗双链-DNA抗体阳性患者,阳性率分别为11.7％、1.4％、1.9％,其余指标均为阴性.其中anti-β2-GPI阳性率与健康人群相比有显著提高（11.7％比3.4％）,ACA阳性率低于健康人群（1.4％比4.1％）,差异均有统计学意义（P值均＜0.05）.而抗单链-DNA抗体阳性率与健康人群的差异无统计学意义.结论 anti-β2-GPI对于CP的诊疗具有潜在价值,ACA的临床意义尚不确定.Objective To explore the positive rate of each autoimmunity parameters in patients with chronic pancreatitis.Methods Four hundred and nine chronic pancreatitis patients treated in Department of Gastroenterology of Changhai Hospital were selected and the 25 autoimmunity parameters included anti-ENA antibody,anti-neutrophil cytoplasmic antibody,anti-β2-GPI,anticardiolipin antibody （ACA）,anti dsDNA antibody were determined,then a literature search was performed to compare the autoimmune positive rate of healthy people in Pubmed database with chronic pancreatitis patients.Results Among 409 patients,the positive rates of anti β2-GPI,ACA,and anti dsDNA antibody were 11.7%,1.4%,and 1.9%,respectively,whereas other indicators were negatively expressed.The positive rate of anti β2-GPI in CP patients was significantly higher than that of healthy group （11.7% vs 3.4%）,and the positive rate of ACA was lower than that of healthy group （1.4% vs 4.1%）,and the difference between the two groups was statistically significant （P 〈 0.05）.Conclusions Anti β2-GPI shows some potential value in the diagnosis and treatment of chronic pancreatitis,but the clinical significance of ACA is uncertain.

关 键 词：胰腺炎 慢性 自身免疫疾病 生物学标记 抗β2-糖蛋白1抗体 anti-β2 GLYCOPROTEIN 1 

分 类 号：R576[医药卫生—消化系统]