查尔酮类化合物的抗癌活性研究进展  

Research advance of the anti-cancer activity of chalcone compounds

作　　者：王永波[1] 木合布力.阿布力孜 

机构地区：[1]新疆医科大学药学院药化有机教研室,乌鲁木齐830011

出　　处：《西北药学杂志》2015年第3期325-329,共5页Northwest Pharmaceutical Journal

基　　金：国家自然科学基金(编号:81260379);新疆研究生科研创新项目(编号:XJGRI2014094)

摘　　要：目的从传统天然药物中筛选出结构新颖、生物活性较强、安全有效的抗癌先导化合物。方法通过比较多种含杂环结构查尔酮类化合物及其抗癌机制来进行分析论证。结果在查尔酮结构中,引入不同的基团、改变结构相对构型等使所得化合物的抗癌活性有所提高。结论杂环查尔酮类化合物显示出较强的抗癌生物活性,根据其构型关系,从传统天然药物筛选出结构新颖、生物活性较强、安全有效的抗癌先导化合物。Objective To screen the lead compounds of anti‐cancer with the characteristics of novel structure ,strong biological activ‐ity ,safe and effective from the traditional natural medicines .Methods Varieties of heterocyclic structure and its anticancer mechanism of chalcone were analyzed and discussed .Results In the structure of chalcone ,the biological activity of chalcone compounds can be improved by the introduction of different groups ,changing the structure of relative configuration and so on .Conclusion Heterocyclic chalcones have strong anti‐cancer biological activity .According to its structure‐activitity relationship ,lead compounds of anti‐cancer ,which have novel structure ,strong biological activity ,safe and effective ,could be selected from the traditional natural medicines .

关 键 词：查尔酮类化合物 抗癌活性 杂环 

分 类 号：R914[医药卫生—药物化学]