USP9X在非小细胞肺癌中的表达及与临床病理特征的关系  

Expression of USP9X in Non-small Cell Lung Cancer and Its Clinical Significance

作　　者：彭静[1,2] 胡倩[1,2] 刘卫平[3] 刘珊玲[1,2] 王和[1,2] 

机构地区：[1]四川大学华西第二医院妇产科,成都610041 [2]四川大学华西第二医院妇儿疾病与出生缺陷教育部重点实验室,成都610041 [3]四川大学华西医院病理科,成都610041

出　　处：《四川大学学报（医学版）》2015年第3期413-416,共4页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(No.81270660);四川省科技厅科技支撑计划项目(No.2012SZ0136);四川省科技厅"神经疾病四川省青年科技创新研究团队"(No.2011JTD0005)资助

摘　　要：目的探讨泛素特异性蛋白酶9X(USP9X)蛋白在非小细胞肺癌(NSCLC)及肺良性病变组织中的表达特点及其临床意义。方法采用免疫组织化学染色方法检测71例NSCLC及20例肺良性病变组织中USP9X蛋白的表达,并分析其中51例NSCLC患者肺癌组织标本中USP9X的表达与患者临床病理特征及预后的关系。结果NSCLC患者USP9X的阳性表达率为69.0%(49/71),较肺良性病变患者阳性表达率20.0%(4/20)高,差异有统计学意义(P<0.001)。NSCLC组织中USP9X的表达在不同肿瘤分化程度及有无淋巴结转移间的差异有统计学意义(P均<0.05)。生存分析中,USP9X阳性表达组患者的生存率低于阴性表达组(P<0.05)。Cox多因素回归分析显示肿瘤的病理类型、TNM分期及USP9X表达是影响NSCLC患者预后的独立危险因素(P均<0.05)。结论 USP9X的过表达在NSCLC的侵袭转移及发生发展中起重要作用,并对肿瘤患者的预后判断有一定参考价值。Objective To investigate the expression and clinical significance of ubiquitin-specific protease 9X（USP9X）protein in non-small cell lung cancer（NSCLC）.Methods USP9 Xproteins were detected in 71 cases of NSCLC and 20 cases of benign pulmonary tissues by immunohistochemical staining.The correlation between USP9 X expression and 51 NSCLC clinicopathological parameters as well as survival rates were indicated.Results Higher rate〔69.0%（49/71）〕of the expression of USP9 Xwas observed in NSCLC samples,compared with 20.0%（4/20）in benign pulmonary tissues（P〈0.001）.Furthermore,the expression of USP9 Xproteins was positively associated with both histological types and lymph node metastasis（P〈0.05）.The survival analysis showed that the survival rate was lower in patients with positive expressions of USP9 Xthan in patients with negative expressions（P〈0.05）.USP9 Xexpression,together with histological types and TNM stage was an independent predictor for overall survival in the multivariate Cox regression model（P〈 0.05）.Conclusion Up-regulation of USP9 X plays an important role in the invasion and progression of NSCLC and could be considered as a prognostic predictor for NSCLC.

关 键 词：肺肿瘤 USP9X 生存 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]