格列美脲的波谱特征与结构确证  

Spectral characteristic analysis and structure identification of glimepiride

作　　者：尹文龙[1] 郝英魁[2] 蒋庆峰[2] 

机构地区：[1]天津中医药大学,天津300193 [2]天津药物研究院药物分析测试中心,天津300193

出　　处：《中南药学》2015年第4期365-368,共4页Central South Pharmacy

摘　　要：目的建立确立格列美脲化学结构的方法。方法通过紫外光谱,红外光谱,质谱,核磁共振,热分析及X-射线粉末衍射对格列美脲的结构进行结构分析。结果通过解析证实了格列美脲的化学结构为1-[4-[2-(3-乙基-4-甲基-2-氧代-3-吡咯啉-1-甲酰胺基)-乙基]-苯磺酰]-3-(反式-4-甲基环己基)-脲。结论该方法准确可行,可为格列美脲的结构鉴定提供依据。Objective To establish a method to identify the chemical structure of glimepiride. Methods UV, IR, MS, NMR, DSC, and X- ray powder diffraction were useed to analyze the chemical structure of glimepiride. Results The chemical structure of glimepiride was 1-[[p-[2-（3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido） ethyl] phenyl] sulfonyl]-3-（trans-4-methylcyclohexyl） urea. Conclusion The method is accurate,and practical which cand can provide a comprehensive reference for structural identification of glimepiride.

关 键 词：格列美脲 结构确证 核磁共振 红外光谱 紫外光谱 质谱 热分析 X-射线粉末衍射 

分 类 号：R914[医药卫生—药物化学]