人肿瘤扩增子形成机制的研究进展  

Study on Formation Mechanisms of Amplicons in Human Cancers

作　　者：李洁[1] 孟祥宁[1] 

机构地区：[1]哈尔滨医科大学医学遗传学研究室,黑龙江哈尔滨150081

出　　处：《肿瘤学杂志》2015年第5期423-427,共5页Journal of Chinese Oncology

基　　金：国家国际科技合作专项(2013DFA31610);国家自然科学基金(81372784;81101646)

摘　　要：基因扩增形成的扩增子可增加细胞中致癌基因的转录和表达,常见于多种人类肿瘤,并且与肿瘤的发生、发展及耐药等密切相关。因此,扩增子形成机制的研究对于肿瘤的治疗具有重要意义。扩增子形成的机制非常复杂,涉及染色体的断裂和重新连接。文章综述了现已发现的与扩增子形成相关的染色体重组机制及已建立的扩增子形成机制模型,希望为进一步的科学研究和临床上肿瘤的靶向治疗提供新的思路。Amplicons,which come from gene amplification,may enhance oncogene transcription and expression ,and are often found in various cancer cells. Emerging evidence suggests that amplicons have an important role in cancer development,progression and drug resistance. Un- derstanding the mechanisms of amplicons formation could be of great significance for clinical treatment of cancers. Chromosome breakage and rejoining are proven to be involved in complex amplieons formation. This review summarizes current understanding of amplieons formation re- lated chromosome recombination and models, and provides new ideas for further scientific re- search and clinical targeted therapy of cancers.

关 键 词：扩增子 肿瘤 染色体 

分 类 号：R73[医药卫生—肿瘤]