中国9省/自治区成年居民膳食胆固醇摄入与高胆固醇血症关系的前瞻性研究  

A cohort study on dietary cholesterol intake and hypercholesterolemia among adults in 9 provinces and autonomous regions

作　　者：杜文雯[1] 欧阳一非[1] 王惠君[1] 王志宏[1] 苏畅[1] 张继国[1] 张伋[1] 姜红如[1] 张兵[1] 

机构地区：[1]中国疾病预防控制中心营养与健康所,北京100050

出　　处：《中华流行病学杂志》2015年第6期594-597,共4页Chinese Journal of Epidemiology

基　　金：达能营养中心膳食营养研究与宣教基金（DIC2013-02）;中国疾病预防控制中心和美国北卡罗莱纳大学人口中心合作项目（R01-HD30880,DK056350,R01-HD38700）;国家自然科学基金（81172666）

摘　　要：目的 探讨成年居民膳食胆固醇摄入与高胆固醇血症的关系.方法 利用“中国健康与营养调查”数据,本研究中纳入的研究对象为同时参加2004年和2009年2轮调查、且在2009年调查时年龄为25- 65岁、血样检测和膳食调查数据完整的成年居民,共4 244人.以《中国成人血脂异常防治指南2007》为标准,血清TC≥6.22 mmol/L时,判定为高胆固醇血症.采用非条件logistic回归方法,研究膳食胆固醇摄入与高胆固醇血症的关系.结果 2009年成年居民平均血清TC水平为4.9 mmol/L,高胆固醇血症患病率为9.6％.2004-2009年膳食胆固醇摄入量总体呈大幅增长,尤其是低摄入量组的增幅最大.男性成年居民中2004年膳食胆固醇摄入中低水平者和2009年膳食胆固醇摄入高水平者,高胆固醇血症患病风险增加.女性膳食胆固醇摄入与高胆固醇血症之间未见统计学关联.结论 膳食胆固醇摄入与高胆固醇血症的关系具有性别差异.膳食胆固醇摄入水平升高,可增加男性居民发生高胆固醇血症的危险性。Objective To explore the association between dietary cholesterol intake and hypercholesterolemia among Chinese adults.Methods In 2009,4 244 adults aged 25-65 years old who participated in both 2004 and 2009 China Health and Nutrition Surveys,and with complete biochemical and dietary data were selected.Hypercholesterolemia were defined as with total cholesterol ≥6.22 mmol/L,according to 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults,Non-conditional logistic regression was used to investigate association between dietary cholesterol intake and hypercholesterolemia.Results The average total cholesterol was 4.9 mmol/L,with prevalence of hypercholesterolemia as 9.6%,in 2009.During 2004 to 2009,dietary cholesterol showed a dramatical increase,with lower intake groups the most.Males who consumed middle or lower dietary cholesterol in 2004 and high intake in 2009 had significantly higher risk of having hypercholesterolemia.However,similar findings did not appear in females.Conclusion The associations between dietary cholesterol intake and hypercholesterolemia were different among Chinese males and females.Dramatic increase of dietary cholesterol intake was related to higher risk of hypercholesterolemia in males.

关 键 词：胆固醇 高胆固醇血症 膳食 前瞻性研究 

分 类 号：R589.2[医药卫生—内分泌]