MTHFR基因C677T和A1298C多态性与精神分裂症关联的家系研究  

Family-based association study about C677T and A1298C polymorphisms in MTHFR gene with schizophrenia

作　　者：周胜利[1,2] 刘兆云[1,2] 刘苗[1,2] 刘金同[3] 张燕[3] 陈刚[1] 陈星[1] 

机构地区：[1]山东省医学科学院基础医学研究所,山东济南250062 [2]济南大学,山东省医学科学院医学与生命科学学院 [3]山东省精神卫生中心

出　　处：《精神医学杂志》2015年第2期85-88,共4页Journal of Psychiatry

基　　金：国家自然科学基金项目(编号:30440042;30770780);山东省自然科学基金项目(编号:ZR2013HM078);山东省科技发展计划项目(编号:2011GSF11821);山东省医学科学院项目(编号:2012-25)

摘　　要：目的探讨MTHFR基因的C677T和A1298C多态位点与精神分裂症的关系。方法采用高分辨率熔解曲线对103个精神分裂症核心家系的C677T与A1298C多态性位点进行SNP分型,通过传递不平衡分析(TDT)和Log线性模型进行数据分析。结果 TDT分析未发现C677T与A1298C多态性位点由杂合型亲代向患者的优势传递(P=0.753,0.492)。Log线性模型显示患者母亲MTHFR C677T与A1298C的单位点分析(C677T P=0.415,A1298C P=0.846)及单体型分析(P=0.607)均无特定亲代配型的聚集。结论 MTHFR基因的C677T与A1298C位点的单核苷酸多态性与精神分裂症的发病无关。Objective To investigate the association between polymorphisms of C677T and A1298C in MTHFR gene with schizophrenia.Methods Single nucleotide polymorphisms of C677T and A1298C in MTHFR gene were genotyped in 103 nuclear families of schizophrenia by using high resolution melting curve.The genetic analysis was performed by using transmission disequilibrium test （TDT）and Log linear model analysis.Results TDT analysis showed no preferential transmission from parents heterozygous to probands with schizophrenia for C677T and A1298C （P =0.753,0.492 respectively）.No significant asymmetry of parental mating type was found in single locus analysis （P value was 0.415 for C677T and 0.846 for A1298C）or haplotype analysis （P =0.607）in Log linear model of maternal datas.Conclusion Single nucleotide polymorphisms of C677T and A1298C allele in MTHFR gene is not likely to be associated with the pathogenesis of schizophrenia.

关 键 词：精神分裂症 关联分析 MTHFR基因 单核苷酸多态 高分辨率熔解曲线 

分 类 号：R749.3[医药卫生—神经病学与精神病学]