Micro RNA-124 slows down the progression of Huntington's disease by promoting neurogenesis in the striatum  

作　　者：Tian Liu Wooseok Im Inhee Mook-Jung Manho Kim 

机构地区：[1]Department of Biomedical Sciences,Seoul National University College of Medicine [2]Department of Neurology,Biomedical Research Institute,Seoul National University Hospital [3]Department of Biochemistry,Seoul National University College of Medicine [4]Protein Metabolism Medical Research Center,College of Medicine,Seoul National University

出　　处：《Neural Regeneration Research》2015年第5期786-791,共6页中国神经再生研究（英文版）

基　　金：supported by a grant(A121911 and HI14C2348)of the Korean Health Technology R&D Project,Ministry of Health&Welfare;National Research Foundation of Korea(NRF)(2011-0012728 and 2014R1A2A1A11051520)

摘　　要：MicroRNA-124 contributes to neurogenesis through regulating its targets, but its expression both in the brain of Huntington＇s disease mouse models and patients is decreased. However, the effects of microRNA-124 on the progression of Huntington＇s disease have not been reported. Results from this study showed that microRNA-124 increased the latency to fall for each R6/2 Hunting- ton＇s disease transgenic mouse in the rotarod test. 5-Bromo-2＇-deoxyuridine （BrdU） staining of the striatum shows an increase in neurogenesis. In addition, brain-derived neurotrophic factor and peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein levels in the striatum were increased and SRY-related HMG box transcription factor 9 protein level was de- creased. These findings suggest that microRNA-124 slows down the progression of Huntington＇s disease possibly through its important role in neuronal differentiation and survival.MicroRNA-124 contributes to neurogenesis through regulating its targets, but its expression both in the brain of Huntington＇s disease mouse models and patients is decreased. However, the effects of microRNA-124 on the progression of Huntington＇s disease have not been reported. Results from this study showed that microRNA-124 increased the latency to fall for each R6/2 Hunting- ton＇s disease transgenic mouse in the rotarod test. 5-Bromo-2＇-deoxyuridine （BrdU） staining of the striatum shows an increase in neurogenesis. In addition, brain-derived neurotrophic factor and peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein levels in the striatum were increased and SRY-related HMG box transcription factor 9 protein level was de- creased. These findings suggest that microRNA-124 slows down the progression of Huntington＇s disease possibly through its important role in neuronal differentiation and survival.

关 键 词：nerve regeneration microRNA-124 NEUROGENESIS neuronal survival Huntington＇sdisease SRY-related HMG box transcription factor 9 brain-derived neurotrophic factor peroxisomeproliferator-activated receptor gamma coactivator 1-alpha mutant huntingtin 

分 类 号：R742.2[医药卫生—神经病学与精神病学]