ERK1/2通路及其介导多发性硬化发病的研究进展  

Research Development of ERK1/2 Pathway and Its Mediated Multiple Sclerosis

作　　者：李鑫[1] 朱文浩[2] 高颖[3] 

机构地区：[1]山东中医药大学附属医院,济南250000 [2]淄博市中医医院,淄博255300 [3]北京中医药大学东直门医院,北京100700

出　　处：《世界科学技术-中医药现代化》2015年第4期880-884,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上项目(81072770):小胶质细胞介导实验性自身免疫性脑脊髓炎神经损伤及其中药复方作用机制研究;负责人:高颖

摘　　要：丝裂原活化蛋白激酶1/2(ERK1/2)通路是第一个被发现的细胞信号转导通路,由Ras、Raf、MEK1/2和ERK1/2组成。ERK1/2通路激活后可以将细胞外信号从细胞膜转到细胞核,参与了细胞的多种生理病理功能,如细胞的生长、增殖、分化和凋亡等,并且与多种疾病的发病有关,包括多发性硬化(MS)和实验性自身免疫性脑脊髓炎(EAE)。ERK1/2通路的激活可以引起星形胶质细胞、MG、T细胞、巨噬细胞等活化,释放多种炎性因子,引起髓鞘损伤,导致MS/EAE的发病。多项研究表明,通过抑制ERK1/2通路可以减少炎性因子的释放,减轻髓鞘损伤,改善MS/EAE的病情,为治疗MS药物的开发提供了重要的靶点。Extracellular signal-regulated kinases 1 and 2 （ERK1/2） pathway, which was the first cell signal transduction pathway to be discovered, consisted of Ras, Raf, MEK1/2 and ERK1/2. After the activation of ERK1/2 pathway, extracellular signals can be transmitted from the cell membrane to the nucleus. It was involved in many physiological and pathological functions of cells, such as growth, proliferation, differentiation, apoptosis and etc. It was also related to the onset of many diseases, which included multiple sclerosis （MS） and experimental autoimmune encephalomyelitis （EAE）. The activation of ERK1/2 pathway can induce the activation of astrocyte, MG, T cell and maerophage, which released a variety of inflammatory cytokines. It caused myelin damage which induced MS/ EAE onset. A number of studies indicated that inhibiting ERK1/2 pathway can reduce the releasing of inflammatory cytokines and myelin damage for MS/EAE alleviation. It provided an important target for the development of MS treatment medication.

关 键 词：丝裂原活化蛋白激酶1/2 多发性硬化 实验性自身免疫性脑脊髓炎 RAS RAF MEK1/2 ERK1/2 

分 类 号：R744.51[医药卫生—神经病学与精神病学]