1-甲基-3-甲酰基吲哚-2-甲酸甲酯的合成  

Synthesis of Methyl 3-formyl-1-methyl-1H-indole-2-carboxylate

作　　者：吴卓[1] 郭伟英[2] 谢洪磊[2] 

机构地区：[1]辽宁医学院附属第一医院 [2]辽宁医学院药学院,辽宁锦州121001

出　　处：《辽宁医学院学报》2015年第3期7-9,共3页Journal of Liaoning Medical University (LNMU) Bimonthly

摘　　要：目的合成1-甲基-3-甲酰基吲哚-2-甲酸甲酯。方法以吲哚-2-甲酸和甲醇为原料经过酯化反应,甲基化和Vilsmeier-haack反应得到标题化合物,总收率为90.3%。结果本方法具有反应条件温和、收率高、易于纯化的特点,为目标化合物的合成提供了新途径。经过核磁共振氢谱和液相-质谱联用对产物进行了结构表征。结论该工艺具有收率高、操作简单、安全可靠的特点并且为工业化生产提供参考。Objective To synthesize methyl 3 - formyl - 1 methyl - 1H - indole - 2 - carboylate. Methods With 1H - indole - 2 - carboxylic acid and methanol as starting material, the compound mentioned above was synthesized after esterification as well as reaction of methylation and Vilsmeier - haack, with a total yield of 90. 3%. Results This method boasted the advantages of mild reaction condition, high yield, and easy purification, providing a new way of synthesis of target compound. The structure characterization of the product was completed with 1H - NMR and LC - MS. Conclusion The method has advantages of high yield, simple operation and safety, with reference value for industrialized production..

关 键 词：吲哚-2-甲酸 1-甲基-3-甲酰基吲哚-2-甲酸甲酯 合成 

分 类 号：R914.2[医药卫生—药物化学]