青少年分化型甲状腺癌^131 I治疗的临床观察  

Clinical observation of ^131 I in rt eatment of adolescents with differentiated thy roid caric no ma

作　　者：王迪[1] 何月涵[2] 王兴华[1] 于红波[1] 王玉君[1] 崔亚利[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院核医学科,哈尔滨150081 [2]哈尔滨医科大学生物信息科学与技术学院

出　　处：《实用肿瘤学杂志》2015年第3期193-196,共4页Practical Oncology Journal

基　　金：黑龙江省卫生厅科研课题（2012-672）

摘　　要：目的：探讨青少年分化型甲状腺癌的临床特点及^131 I治疗的临床疗效。方法回顾性分析2011年1月—2013年1月收治的181例分化型甲状腺癌患者的临床资料及随访结果，其中包括青少年患者（21岁及以下）36例，非青少年患者（21岁以上）145例，所有患者均进行^131 I治疗，并进行随访。结果青少年组的淋巴结转移和远处转移发生率均高于非青少年组（P＜0．05）。青少年组患者^131I治疗的有效率为91．7％，非青少年组患者有效率为82．1％。青少年组患者随访期内未发现^131I 治疗引起肺纤维化、生长发育异常和继发肿瘤等不良事件发生。结论青少年分化型甲状腺癌更易发生局部淋巴结转移或远处转移，^131 I治疗青少年分化型甲状腺癌是一种安全有效的方法。Objective To investigate the clinical characteristics and effect of the ^131 I therapy in the ado-lescents with differentiated thyroid carcinoma .Methods The clinical and follow up data of 181 patients with dif-ferentiated thyroid carcinoma who received initial ^131 I treatment from January 2011 to January 2013 were retro-spectively analyzed.There were 36 cases of adolescent patients （21 years old or younger）,and 145 cases of adult patients（More than 21 years old）.Results The incidence of lymph node metastasis and distant metastasis in ad-olescent group were higher than that in the non -adolescent group （ P〈00.5 ） .The effective rate of adolescent pa-tients with ^131 I treatment was 91.7%,and the effective rate was 82.1%in non-adolescent group .No pulmonary fibrosis,abnormity of growth and secondary malignancies were found during follow -up.Conclusion Adolescent patients with differentiated thyroid cancer are more likely to occur local lymph node metastasis or distant metasta -sis.^131 I therapy is an effective and safe method for young patients with differentiated thyroid carcinoma .

关 键 词：^131I 甲状腺癌 青少年 临床观察 

分 类 号：R730.55[医药卫生—肿瘤]