齿叶白鹃梅叶中黄酮类化合物对α-葡萄糖苷酶的抑制活性研究  

Inhibitory activity of flavonoids isolated from Exochorda serratifolia S. Moore. on α-glucosidase

作　　者：李古月[1,2] 刘佳鑫[1,2] 才谦[3] 

机构地区：[1]中国医科大学附属第一医院,沈阳110000 [2]中国医科大学药学院,沈阳110000 [3]辽宁中医药大学药学院,大连116600

出　　处：《天津中医药大学学报》2015年第3期165-168,共4页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81202919)

摘　　要：[目的]研究齿叶白鹃梅叶中分离得到的黄酮类化合物对α-葡萄糖苷酶的抑制作用。[方法]以96微孔板法测定α-葡萄糖苷酶抑制作用。[结果]齿叶白鹃梅叶中多个黄酮类化合物具有α-葡萄糖苷酶抑制活性,其中木犀草素,木犀草素-7-O-β-D-新橙皮糖苷,芹菜素,芹菜素-7-O-β-D-新橙皮糖苷,槲皮素,槲皮素-3-O-β-D-葡萄糖苷对α-葡萄糖苷酶的抑制活性高于阿卡波糖。[结论]黄酮类化合物可能是齿叶白鹃梅叶具有降糖作用的物质基础。[Objective] To investigate the inhibitory activity of flavonoids isolated from Exochorda serratifolia S.Moore. leaves on α-glucosidase.[Methods] Inhibitory activity of α-glucosidase was screened by the 96-microplatebased method.[Results] The flavonoids showed inhibitory activity on α-glucosidase. Among them, luteolin, luteolin-7-O-β-D-neospheroside, apigenin, apigenin-7-O-β-D-neospheroside, quercetin, quercetin-3-O-β-D-glucoside showed stronger inhibitory activity than acarbose.[Conclusion] Flavonoids may be the substances basis of Exochorda serratifolia S. Moore. leaves with inhibitory activity of α-glucosidase.

关 键 词：齿叶白鹃梅叶 黄酮 Α-葡萄糖苷酶 抑制活性 

分 类 号：R285.5[医药卫生—中药学]